Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer
Reexamination Certificate
2006-10-24
2006-10-24
Webman, Edward J. (Department: 1616)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Aftertreated polymer
C424S078350, C514S824000
Reexamination Certificate
active
07125547
ABSTRACT:
The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3–C24-alkyl group, an aralkyl group or an aryl group.
REFERENCES:
patent: 2874132 (1959-02-01), Riener
patent: 3288770 (1966-11-01), Butler
patent: 3308020 (1967-03-01), Wolf et al.
patent: 3383281 (1968-05-01), Wolf et al.
patent: 3562266 (1971-02-01), Minisci et al.
patent: 3585118 (1971-06-01), Harada et al.
patent: 3692895 (1972-09-01), Nelson et al.
patent: 3780171 (1973-12-01), Irmscher et al.
patent: 3787474 (1974-01-01), Daniels et al.
patent: 3801641 (1974-04-01), Payot et al.
patent: 3803237 (1974-04-01), Lednicer et al.
patent: 3833531 (1974-09-01), Keim
patent: 3840504 (1974-10-01), Keim
patent: 3980770 (1976-09-01), Ingelman et al.
patent: 4027009 (1977-05-01), Grier et al.
patent: 4071478 (1978-01-01), Shen et al.
patent: 4098726 (1978-07-01), Wagner et al.
patent: 4101461 (1978-07-01), Strop et al.
patent: 4111859 (1978-09-01), Strop et al.
patent: 4205064 (1980-05-01), Wagner et al.
patent: 4217429 (1980-08-01), Wagner et al.
patent: 4287172 (1981-09-01), Jacquet et al.
patent: 4340585 (1982-07-01), Borzatta et al.
patent: 4360434 (1982-11-01), Kawaguchi et al.
patent: 4426489 (1984-01-01), Wessling et al.
patent: 4540760 (1985-09-01), Harada et al.
patent: 4557930 (1985-12-01), Kihara et al.
patent: 4559391 (1985-12-01), Ueda et al.
patent: 4605701 (1986-08-01), Harada et al.
patent: 4680360 (1987-07-01), Ueda et al.
patent: 4759923 (1988-07-01), Buntin et al.
patent: 4812540 (1989-03-01), Kageno et al.
patent: 5055197 (1991-10-01), Albright et al.
patent: 5185411 (1993-02-01), Jueptner et al.
patent: 5189111 (1993-02-01), Danner
patent: 5236701 (1993-08-01), St. Pierre et al.
patent: 5374422 (1994-12-01), St. Pierre et al.
patent: 5414068 (1995-05-01), Bliem et al.
patent: 5428112 (1995-06-01), Ahlers et al.
patent: 5430110 (1995-07-01), Ahlers et al.
patent: 5451397 (1995-09-01), Albright et al.
patent: 5462730 (1995-10-01), McTaggart et al.
patent: 0 081 291 (1983-06-01), None
patent: 0 162 388 (1985-11-01), None
patent: 0 280 445 (1988-08-01), None
patent: 0 373 852 (1990-06-01), None
patent: 0 401 705 (1990-12-01), None
patent: 0 432 995 (1991-06-01), None
patent: 0 459 632 (1991-12-01), None
patent: 798488 (1958-07-01), None
patent: 929391 (1963-06-01), None
patent: 1567294 (1980-05-01), None
patent: 2 090 605 (1982-07-01), None
patent: 2 227 663 (1990-08-01), None
patent: 56010531 (1981-02-01), None
patent: 57047302 (1982-03-01), None
patent: 57125233 (1982-08-01), None
patent: 62170591 (1987-07-01), None
patent: 62257481 (1987-11-01), None
patent: 02001358 (1990-01-01), None
patent: 7316061 (1995-12-01), None
patent: WO91/18027 (1991-11-01), None
patent: WO92/10522 (1992-06-01), None
patent: WO94/04596 (1994-03-01), None
patent: WO94/27620 (1994-12-01), None
patent: WO95/34585 (1995-12-01), None
patent: WO95/34588 (1995-12-01), None
Heming, A.E., et al., “Considerations in the Selection of Cation Exchange Resins for Therapeutic Use,”Annals of the New York Academy of Sciences, 57:239-251 (1954).
McCarthy, Peter A., “New Approaches to Atherosclerosis: An Overview,”Medicinal Research Reviews, 13(2): 139-159 (1993).
Butler, G.B., et al., “Comblike Cyclopolymers of Alkyldiallylamines and Alkyldiallylmethylammonium Chlorides,” inWater-Soluble Polymers, eds. Shalaby, McCormick & Butler, Chapter 9, pp. 151-158 ACS Symposium Series 467 (1991).
Dubin, P.L., et al., “Quasi-Elastic Light Scattering of Polyelectrolyte-Micelle Complexes,”Macromolecules17:1294-1296 (1984).
Wang, G.-J., et al., “Fluorescence probing of the formation of hydrophobic microdmains by cross-linked poly (alkylmethyldiallyl-ammonium bromides) in aqueous solution,”Recl. Trav. Chim. Pays-Bas113:390-393 (1994).
Kunitake, T., et al., “Catalyses of Polymer Complexes. 4. Polysoap-Catalyzed Decarboxylation of 6-Nitrobenzisoxazole-3-carboxylate Anion. Importance of the Hydrophobic Environment in Activation of the Anion,”J. Org. Chem42(2):306-312 (1977).
Wang, G.-J., et al., “Study of the Conformational State of Non-Cross-Linked and Cross-Linked Poly (alkylmethyldiallylammonium Chlorides) in Aqueous Solution by Fluorescence Probing,”Gazzetta Chimica Italiana, 125:393-397 (1995).
Kuron, G.W., et al., “The Bile Acid Binding and Hypocholesterolemic Action of Two Water-Soluble Polymers,”Atherosclerosis, 37:353-360 (1980).
Harada, S., et al., “The Cyclo-copolymerization of Diallyl Compounds and Sulfur Dioxide,”Die Makromolekulare Chemie, 107:64-93 (1967).
Wang, G.-J., et al., “Induction of Aggregate Formation of Cationic Polysoaps and Surfactants by Low Concentrations of Additives in Aqueous Solution,”Langmuir, 10(8):2583-2587 (1994).
Wang, G.-J, et al., “Synthesis of Hydrophobically and Electrostatically Modified Polyacrylamides and Their Catalytic Effects on the Unimolecular Decarboxylation of 6-Nitrobenzisoxazole-3-carboxylate Anion,”Langmuir, 11(10):3856-3861 (1995).
Wang, G.-J., et al., “Synthesis and Catalytic Properties on Non-Cross-Linked and Cross-linked Cross-Linked Poly (alkylmethyldiallylammonium Bromides) Having Decyl, Octyl, and Hexyl Side Chains,”J. Org. Chem, 60:4030-4038 (1995).
Kevelam, J., et al., “Polymer-Surfactant Interactions Studied by Titration Microcalorimetry: Influence of Polymer Hydrophobicity, Electrostatic Forces, and Surfactant Aggregational State,”Langmuir, 12(20):4709-4717 (1996).
Wang, G.-J., et al., “Synthesis and Catalytic Properties of Cross-Linked Hydrophobically Associating Poly (alkylmethyldiallyl-ammonium bromides),”J. Org. Chem., 59(15):4076-4081 (1994.).
Yang, Y.J., et al., “Synthesis and Catalytic Properties of Hydrophobically Modified Poly (alkylmethyldiallylammonium bromides),”J. Org. Chem., 56:4300-4304 (1991).
Negi, Y., et al., “Cyclopolymerization of Diallylamine Derivatives in Dimethyl Sulfoxid,”J. Polymer Science: Part A-I, 5:1951-1965 (1967).
Hodgkin, H., et al., “Use of13C-NMR in the Study of Reactions of Crosslinked Resins,” Published by John Wiley & Sons,J. of Polymer Science: Polymer Chemistry Edition, 19(5):1239-1249 (1981).
Yeh, F., et al., “Nanoscale Supramolecular Structures in the Gels of Poly (Diallyldimethylammonium Chloride) Interacting with Sodium Dodecyl Sulfate,”J. Am. Chem. Soc., 118(28):6615-6618 (1996).
Boothe, J.E., et al., “Some Homo- and Copolymerization Studies of Dimethyldiallylammonium Chloride,”J. Macromol. Sci. -Chem., A4(6):1419-1430 (1970).
McLean, C.D., et al., “Cyclopolymerization. VI. Preparation and Properties of Crosslinked Polyamines by Cyclopolymerization,”J. Macromol. Sci.-Chem., A10(5):857-873 (1976).
Bolto, B.A, et al., “Synthesis of Cross-Linked Polyallylamines which are Resistant to Sulfite Attack,”J. Macromol. Sci. Chem., A17(1):153-166 (1982).
Dhal Pradeep K.
Petersen John S.
LandOfFree
Poly(diallylamine)-based bile acid sequestrants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Poly(diallylamine)-based bile acid sequestrants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Poly(diallylamine)-based bile acid sequestrants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3677719