Human cDNAs and proteins and uses thereof

Details Human cDNAs and proteins and uses thereof Human cDNAs and proteins and uses thereof

2006-02-28

2006-02-28

Wax, Robert A. (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

07005500

ABSTRACT:
The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.

REFERENCES:
patent: 5340934 (1994-08-01), Termine et al.
Sasaki et al., “Crystal structure and mapping by site-directed mutagenesis fo the collagen-binding epitope of an activated for of BM-40/SPARC/osteonectin”, 1998, EMBO J., 17(6), 1625-34.
Accession: A32821; Villarreal, X.C., et al.; “Structure of human osteonectin based upon analysis of cDNA and genomic sequences”Biochemistry 28, 6483-6491, 1989.
Accession: J03040; Swaroop, A., et al.; “Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33”; Genomics2 (1), 37-14 (1988).
Accession: BC004974; Strausberg, R.; “Direct Submission”; Submitted(Mar. 21, 2001) National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute.
Accession: AAH04974; Strausberg, R.; Submitted (Mar. 2001) to the EMBL/GenBank/DDBJ databases.
Accession: Y00755; Lankat-Buttgereit, et al.; Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin); FEBS Lett. 236 (2), 352-356 (1988).
Xie, Rong-Lin,et al.; “Elements within the First 17 Amino Acids of Human Osteonectin are Responsible for Binding to Type V Collagen”; The Journal of Biological Chemistry, vol. 271, No. 14, Issue of Apr. 5, pp. 8121-8125, 1996; The American Society for Biochemistry and Molecular Biology, Inc.
Sasaki, T., et al., “Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin”; The EMBO Journal, vol. 17, No. 6, pp. 1625-1634, 1998; Oxford University Press.
Nedelec, B., et al., “Rating the Resolving Hypertrophic Scar: Comparison of the Vancouver Scar Scale and Scar Volume”; Journal of Burn Care & Rehabilitation, May/Jun. 2000, vol. 21, No. 3, pp. 205-212.
Kato, Y., et al., “Simulation of Motility of Human Renal Cell Carcinoma by SPARC/Osteonectin/BM-40 Associated with Type IV Collagen”; Invation Metastasis 1998/99;18; 105-114; Received: Oct. 13, 1998; S. Karger AG, Basel.
Nakamura, S., et al.; “Enhancement of SPARC (Osteonectin) Synthesis in Arthritic Cartilege”; Arthritis & Rheumatism; vol. 39, No. 4, Apr. 1996, pp. 539-551; American College of Rheumatology.
Kupprion, C., et al.; “SPARC (BM-40, Osteonectin) Inhibits the Mitogenic Effect of Vascular Endothelial Growth Factor on Microvascular Endothelial Cells”; The Journal of Biological Chemistry, vol. 273, No. 45, Issue of Nov. 6, pp. 29635-29640, 1998; The American Society for Biochemistry and Molecular Biology, Inc.
Delany, A.M., et al., “Osteopenia and decreased bone formation inosteonectin-deficient mice”; The Journal of Clinical Investigation, Apr. 2000, vol. 105, No. 7, pp. 915-923.
Gerber, H., et al., “VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation”; Nature Medicine, vol. 5, No. 6, Jun. 1999, pp. 623-628; Nature America, Inc.
Jacob, K., et al., “Osteonectin Promotes Prostate Cancer Cell Migration and Invasion: A Possible Mechanism for Metastasis to Bone”; Cancer Research, 59, 4453-4457, Sep. 1, 1999.
Raines, E., et al., “The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors”; Proc. Natl. Acad. Sci. USA, vol. 89, pp. 1281-1285, Feb. 1992, Cell Biology.
Xie, R., et al., “Role of N-Linked Glycosylation in Human Osteonectin”; p. 23212-23217; Received for publication Jan. 17, 1995 and in revised from May 26, 1995; from the Department of Biochemistry, School of Medicine, University of Vermont, Burlington, VT.

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