Potassium channel modulators

Details Potassium channel modulators Potassium channel modulators

2006-12-19

2006-12-19

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S312000

Reexamination Certificate

active

07151180

ABSTRACT:
This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.

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Boy, Bioorg & Med Chem Let, vol. 14, 5089-5093, 2004.
P. Hewawasam, et al, “4-Aryl-3-(Hydroxyalkyl)Quinolin-2-Ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction,” J. Med. Chem., 46, pp. 2819-2822, 2003.

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