Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1988-09-27
1989-09-19
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
421481, A61K 946
Patent
active
048679429
ABSTRACT:
Process for the preparation of an effervescent granular material containing at least one solid, crystalline, edible organic acid, particularly citric acid and at least one alkali metal or alkaline earth metal carbonate splitting off CO.sub.2 on reacting with the organic acid in aqueous solution, in which optionally in a vacuum mixing machine, the acid crystals are wetted in a first reaction stage with a solvent for the acid, such as water, alcohol or a mixture thereof and are then thoroughly mixed for forming a first coating with a first pulverized coating compound containing at least one alkali metal or alkaline earth metal carbonate adhering to a binding coating formed by the reaction of acid and carbonate on the surface coating of the particular acid crystal, after which following formation of the first coating in at least one further reaction stage at least one further solid, pulverized coating compound, optionally coinciding with the first and having a content of at least one alkali metal or alkaline earth metal carbonate is added and reacted under vigorous stirring on the preceding coating formed during the preceding reaction stage and moist through the water of crystallization split off during the reaction and finally final drying takes place after breaking off coating formation, wherein part of the total acid quantity and part of the alkali metal and/or alkaline earth metal carbonate of the first coating compound is dissolved in the solvent prior to the appplication thereof to the acid crystals and they are reacted together, the thus prepared prereaction solution then being applied to the acid crystals, the effervescent granular material prepared according to this process and the use thereof.
REFERENCES:
patent: 4036228 (1977-07-01), Theunoves
patent: 4127645 (1978-11-01), Wetzel et al.
patent: 4678661 (1987-07-01), Gergely et al.
Gergely Gerhard
Gergely Irmgard
Gergely Stefan M.
Gergely Thomas
Horne Leon R.
Page Thurman K.
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