Chemical compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S365000

Reexamination Certificate

active

07060702

ABSTRACT:
The present invention provides compounds of formula (I):whereineach R independently represents a halogen atom or a C1-4alkyl group;R1represents a C1-4alkyl group;R2represents hydrogen or a C1-4alkyl group;R3represents hydrogen or C1-4alkyl group;R4represents a trifluoromethyl group;R5represents hydrogen, a C1-4alkyl group or C(O)R6;R6represents C1-4alkyl, C3-7cycloalkyl, NH(C1-4alkyl) or N(C1-4alkyl)2;m is zero or an integer from 1 to 3;n is an integer from 1 to 3;or a pharmaceutically acceptable salt or solvate thereof; compositions containing the same, processes for their preparation and methods for their use in the treatment of conditions mediated by tachykinins.

REFERENCES:
patent: 4087424 (1978-05-01), Saikawa et al.
patent: 4110327 (1978-08-01), Saikawa et al.
patent: 4112090 (1978-09-01), Saikawa et al.
patent: 4219554 (1980-08-01), Saikawa et al.
patent: 4308387 (1981-12-01), Bjork et al.
patent: 4327097 (1982-04-01), Saikawa et al.
patent: 4379152 (1983-04-01), Saikawa et al.
patent: 4410522 (1983-10-01), Saikawa et al.
patent: 5028610 (1991-07-01), Hirai et al.
patent: 5109014 (1992-04-01), Jacobson et al.
patent: 5334606 (1994-08-01), MacLeod et al.
patent: 5348955 (1994-09-01), Greenlee et al.
patent: 5360820 (1994-11-01), Hagan et al.
patent: 5464788 (1995-11-01), Bock et al.
patent: 5538982 (1996-07-01), Hagan et al.
patent: 5563127 (1996-10-01), Amparo et al.
patent: 5576317 (1996-11-01), Gonsalves et al.
patent: 5696123 (1997-12-01), Dollinger et al.
patent: 5698538 (1997-12-01), Amparo et al.
patent: 5708006 (1998-01-01), Dollinger et al.
patent: 5710169 (1998-01-01), Russell et al.
patent: 5716942 (1998-02-01), Dorn et al.
patent: 5756504 (1998-05-01), Bock et al.
patent: 5814636 (1998-09-01), Katano et al.
patent: 5859015 (1999-01-01), Graham et al.
patent: 5883096 (1999-03-01), Lowe et al.
patent: 5935951 (1999-08-01), Ofner et al.
patent: 5952315 (1999-09-01), Baker et al.
patent: 5977104 (1999-11-01), Baker et al.
patent: 5985881 (1999-11-01), Dollinger et al.
patent: 5998444 (1999-12-01), Russell et al.
patent: 6037352 (2000-03-01), Lowe et al.
patent: 6057323 (2000-05-01), Zhang et al.
patent: 6090807 (2000-07-01), Hellendahl et al.
patent: 6114315 (2000-09-01), Baker et al.
patent: 6117855 (2000-09-01), Carlson et al.
patent: 6147083 (2000-11-01), Russell et al.
patent: 6191135 (2001-02-01), Dollinger et al.
patent: 6191139 (2001-02-01), Hagan et al.
patent: 6197772 (2001-03-01), Janssens et al.
patent: 6235732 (2001-05-01), Dollinger et al.
patent: 6288068 (2001-09-01), Lowe et al.
patent: 6319953 (2001-11-01), Carlson et al.
patent: RE37886 (2002-10-01), Janssens et al.
patent: 6521621 (2003-02-01), Janssens et al.
patent: 6642240 (2003-11-01), Alvaro et al.
patent: 2002/0103205 (2002-08-01), Lowe et al.
patent: 2519400 (1978-04-01), None
patent: 287734 (1987-10-01), None
patent: 293532 (1987-10-01), None
patent: 0655442 (1995-05-01), None
patent: 718287 (1995-12-01), None
patent: 0721941 (1996-07-01), None
patent: 0655422 (2001-05-01), None
patent: 1508062 (1975-04-01), None
patent: 57/118587 (1982-07-01), None
patent: WO 92/16211 (1992-10-01), None
patent: WO 95/00498 (1995-01-01), None
patent: WO 95/25443 (1995-09-01), None
patent: WO 96/02503 (1996-02-01), None
patent: WO 96/03378 (1996-02-01), None
patent: WO 96/10562 (1996-04-01), None
patent: WO 96/14844 (1996-05-01), None
patent: WO 96/20173 (1996-07-01), None
patent: WO 97/16440 (1997-05-01), None
patent: WO 97/32865 (1997-09-01), None
patent: WO 97/36592 (1997-10-01), None
patent: WO 97/36593 (1997-10-01), None
patent: WO 97/36888 (1997-10-01), None
patent: WO 97/36889 (1997-10-01), None
patent: WO 98/01133 (1998-01-01), None
patent: WO 98/20001 (1998-05-01), None
patent: WO 98/57954 (1998-12-01), None
patent: WO 99/09985 (1999-03-01), None
patent: WO 99/26921 (1999-06-01), None
patent: WO 01/025219 (2001-04-01), None
patent: WO 02/032867 (2002-04-01), None
patent: WO 02/057233 (2002-07-01), None
patent: WO 04/033428 (2004-04-01), None
Pacher, P., et al. “Review of Cardiovascular Effects of Fluoxetine, A Selective Serotonine Reuptake Inhibitor, Compared to Tricyclic Antidepressants.” Current Medicinal Chemistry, 1998, 5, 381-390.
Megens, A., et al. J. Pharmacology and Experimental Therapeutics (2002)302(2):696-709.
Challet, E., et al. Neuropharmacology (2001) 40(3): 408-415.
Romerio, et al., Clinical Pharmacology and Therapeutics (1999) 66(5):522-527.
Rupniak, et al. “Differential inhibition of foot tapping and chromodacryorrhea in gerbils by CNS penetrant And non-penetrant tachykinin NK1 receptor antagonists,” European Journal of Pharmacology 265:179-183 (1994).
Davis, David T., “Synthesis A. Biological Activity of a Series of Piperazin-2,3-Diones,” Journal of Antibiotics, vol. XLII, No. 3, 1989, pp. 367-373.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chemical compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3672765

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.