Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reissue Patent
2006-10-10
2006-10-10
Zucker, Paul A. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C554S115000, C554S154000
Reissue Patent
active
RE039333
ABSTRACT:
delete-start id="DEL-S-00001" date="20061010" ?This invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid, a useful pharmaceutical intermediate, easily from a readily available, inexpensive starting material without using any extraordinary production equipment such as a very-low-temperature reactor.Thus, this invention provides a process for producing a 5-hydroxy-3-oxopentanoic acidwhich comprises permitting a lithium amide to act upon a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative at not below −20° C.Further, this invention also provides a process for producing a 5-hydroxy-3-oxopentanoic acidwhich comprises treating a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative with a Grignard reagent to prepare a mixture of a compound and an acetic acid ester of the above formula (I),and permitting a lithium amide to act upon the mixture at a temperature not below −20° C.delete-end id="DEL-S-00001" ?insert-start id="INS-S-00001" date="20061010" ?This invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid, a useful pharmaceutical intermediate, easily from a readily available, inexpensive starting material without using any extraordinary production equipment such as a very-low temperature reactor. Thus, this invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid which comprises permitting a lithium amide to act upon a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative at not below −20° C. Further, this invention also provides a process for producing a 5-hydroxy-3-oxopentanoic acid which comprises treating a mixture of an acetic acid ester and a 3-hydroxypropionic acid derivative with a Grignard reagent to prepare a mixture of a compound and an acetic acid ester of the above formula(I), and permitting a lithium amide to act upon the mixture at a temperature not below −20° C.insert-end id="INS-S-00001" ?
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Inoue Kenji
Nishiyama Akira
Connolly Bove & Lodge & Hutz LLP
Kaneka Corporation
Zucker Paul A.
LandOfFree
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