Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2006-11-21
2006-11-21
Borin, Michael (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C702S027000, C530S300000, C530S350000
Reexamination Certificate
active
07139665
ABSTRACT:
The instant invention provides methods, reagents, and computational tools for designing non-natural substrate analogs for enzymes, especially for designing unnatural amino acid analogs for aminoacyl tRNA Synthetases (AARSs), such as the Phe tRNA Synthetase. The instant invention also provides methods to incorporate unnatural amino acid analogs, especially those with interesting functional groups, into protein products to generate proteins of modified or novel functions.
REFERENCES:
patent: 6269312 (2001-07-01), Mayo et al.
patent: 2001/0051855 (2001-12-01), Wang et al.
patent: 2002/0004706 (2002-01-01), Mayo et al.
patent: 2002/0072864 (2002-06-01), Lacroix et al.
Ohno et al (J Biochem (Tokyo), Sep. 2001; 130(3):417-23; see abstract.
Datta et al., A Designed Phenylalanyl-tRNA Synthetase Variant Allows Efficient in vivo Incorporation of Aryl Ketone Functionality into Proteins. Journal of the American Chemical Society, 124(20):5652-5653, 2002.
Dahiyat et al., De novo Protein Design: Fully Automated Sequence Selection. Science 278(5335): 82-87, 1997.
Dahiyat and Mayo, Protein Design Automation.Protein Science5: 895-903, 1993.
IBBA et al., Relaxing the Substrate Specificity of an Aminoacyl-tRNA Synthetase Allows in vitro and in vivo Synthesis of Proteins Containing Unnatural Amino Acids. FEBS Letters 364: 272-275, 1994.
OHNO et al., Changing the amino acid specificity of yeast tyrosyl-tRNA synthetase by genetic engineering.J. Biochem(Tokyo). 130(3): 417-23, 2001. (Abstract).
Reshetnikova et al. Crystal Structures of Phenylalanyl-tRNA Synthetase Complexed with Phenylalanine and a Phenylalanyl-adenylate Analogue. Journal of Molecular Biology 287(3): 555-568, 1999.
Zhang et al., Structure-based design of mutantMethanococcus jannaschiityrosyl-tRNA synthetase for incorporation of O-methyl-L-tyrosine.Proc Natl Acad Sci U S A. 99(10): 6579-6584, 2002.
Carrico Isaac
Datta Deepshikha
Mayo Stephen L.
Tirrell David
Wang Pin
Borin Michael
California Institute of Technology
Seed Intellectual Property Law Group PLLC
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