N-carbamoyl derivatives of (5,4b)-isothiazolo pyridine-3-one and

Details N-carbamoyl derivatives of (5,4b)-isothiazolo pyridine-3-one and N-carbamoyl derivatives of (5,4b)-isothiazolo pyridine-3-one and

1983-04-13

1985-04-23

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546114, 514859, A61K 31425

Patent

active

045129851

ABSTRACT:
N-carbamoyl derivatives of (5,4b)-isothiazolo pyridine-3-one have the formula ##STR1## wherein R.sub.1 represents hydrogen, linear or branched alkyl having 1-12 carbon atoms, cycloalkyl having 3-6 carbon atoms or ##STR2## wherein n is 0 or 1, x is 1, 2 or 3, R.sub.2 represents hydrogen or lower alkyl having 1-3 carbon atoms and R.sub.3 represents hydrogen, lower alkyl having 1-3 carbon atoms, nitro, trifluoromethyl or halogen. These derivatives are useful in the treatment of acne.

REFERENCES:
patent: 3965107 (1976-06-01), Rainey et al.
Fischer et al., "Arzneimittel-Forsch", vol. 14(12), pp. 1301-1306, (1964).
McClelland et al., J. Chem. Soc., pp. 921-926, (1926).

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