Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1998-03-06
2000-04-04
Isabella, David J.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
623 66, A61F 202
Patent
active
060463791
ABSTRACT:
The invention provides an article of manufacture comprising a substantially non-immunogenic knee meniscal xenograft for implantation into humans. The invention further provides methods for preparing a knee meniscal xenograft by removing at least a portion of a meniscus from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; and subjecting the xenograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment and either digestion of the carbohydrate moieties of the xenograft with a glycosidase in a range of about 1 mU/ml to about 1000 U/ml or glycosidase digestion followed by treatment for sialylation. The invention also provides articles of manufacture produced by one or more of the above-identified methods of the invention. The invention further provides a meniscal xenograft for implantation into a human including a portion of a meniscus from a non-human animal, wherein the portion includes extracellular matrix and substantially only dead cells. The matrix and dead cells have substantially no surface .alpha.-galactosyl moieties and have sialic acid molecules linked to at least a portion of surface carbohydrate moieties. Each of the xenografts of the invention is substantially non-immunogenic and has substantially the same mechanical properties as the respective native meniscus.
REFERENCES:
patent: 4034418 (1977-07-01), Jackson et al.
patent: 4344193 (1982-08-01), Kenny
patent: 4400833 (1983-08-01), Kurland
patent: 4502161 (1985-03-01), Wall
patent: 4597266 (1986-07-01), Entrekin
patent: 4609627 (1986-09-01), Goldstein
patent: 4627853 (1986-12-01), Campbell et al.
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4678470 (1987-07-01), Nashef et al.
patent: 4755593 (1988-07-01), Lauren
patent: 4776853 (1988-10-01), Klement et al.
patent: 4789663 (1988-12-01), Wallace et al.
patent: 4801299 (1989-01-01), Brendel et al.
patent: 4846835 (1989-07-01), Grande
patent: 4880429 (1989-11-01), Stone
patent: 4932973 (1990-06-01), Gendler
patent: 5007934 (1991-04-01), Stone
patent: 5067962 (1991-11-01), Campbell et al.
patent: 5071741 (1991-12-01), Brockbank
patent: 5078744 (1992-01-01), Chvapil
patent: 5092894 (1992-03-01), Kenny
patent: 5116374 (1992-05-01), Stone
patent: 5131850 (1992-07-01), Brockbank
patent: 5158574 (1992-10-01), Stone
patent: 5160313 (1992-11-01), Carpenter et al.
patent: 5171273 (1992-12-01), Silver et al.
patent: 5171322 (1992-12-01), Kenny
patent: 5171660 (1992-12-01), Carpenter et al.
patent: 5192312 (1993-03-01), Orton
patent: 5216126 (1993-06-01), Cox et al.
patent: 5306304 (1994-04-01), Gendler
patent: 5306311 (1994-04-01), Stone et al.
patent: 5358525 (1994-10-01), Fox et al.
patent: 5507810 (1996-04-01), Prewett et al.
patent: 5613982 (1997-03-01), Goldstein
Rodrigo et al., Clinical Orthopedics and Related Research, 134:342-349 (1978).
Sengupta et al., The Journal of Bone and Joint Surgery, 56B:167-177 (1974).
Webber et al., Journal of Orthopedic Research, 3:36-42 (1985).
Rubak et al., Acta Orthop. Scand, 53:181-186 (1982).
Engkvist, Ove, Scand. J. Plast. Reconstr. Surg., 13:361-369 (1982).
Collins et al., Xenotransplantation, Characterization of Porcine Endothelial Cell Determinants Recognized by Human Natural Antibodies, 1:36-46 (1994).
Satake et al., Xenotransplanation, Limited Specificity of Xenoantibodies In Diabetic Patients Transplanted With Fetal Porcine Islet Cell Clusters. Main Antibody Reactivity Against .alpha.-linked Galactose-Containing Epitopes, 1:89-101 (1994).
LaVecchio et al., Transplantation, Enzymatic Removal of Alpha-Galactosyl Epitopes From Porcine Endothelial Cells Diminishes The Cytotoxic Effect of Natural Antibodies, 60:841-847.
Stone et al., Arthroscopy: The Journal of Arthroscopic and Related Surgery, 9:234-237 (1993).
Cotterell et al., Transplantation, The Humoral Immune Response in Humans Following Cross-Perfusion of Porcine Organs, 60:861-868 (1995).
Galili, Immunology Today, 14:480-482 (1993).
Elves et al., An Investigation Into The Immunogenicity Of Various Components of Osteoarticular Grafts, The British Journal of Experimental Pathology, 55:344-351 (1974).
Galili Uri
Stone Kevin R.
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