Crystal structure of a deacetylase and inhibitors thereof

Details Crystal structure of a deacetylase and inhibitors thereof Crystal structure of a deacetylase and inhibitors thereof

2006-10-17

2006-10-17

Borin, Michael (Department: 1631)

Data processing: structural design, modeling, simulation, and em

Simulating nonelectrical device or system

Biological or biochemical

Reexamination Certificate

active

07124068

ABSTRACT:
The present invention provides three-dimensional structural information from the hyperthermophilic bacteriumAquifex aeolicuswhich is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.

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