Polyorganofullerenes

Details Polyorganofullerenes Polyorganofullerenes

1997-11-20

2000-04-04

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

568817, C07C30401

Patent

active

060463619

ABSTRACT:
Polyorganofullerene and polyhydroxyorganofullerene derivatives have the respective formulas, F--(E).sub.n and F--(E).sub.n --(OH).sub.m, in which F is a fullerene core; E is a nucleophilic substituent; --OH is a hydroxy group; n is 2-30; and m is 1-20. Also disclosed is a method of preparing such polyorgano-fullerene and polyhydroxyorganofullerene derivatives using polynitrofullerenes or polycyclosulfated fullerenes as intermediates.

REFERENCES:
patent: 5177248 (1993-01-01), Chiang et al.
patent: 5294732 (1994-03-01), Chiang et al.
patent: 5416188 (1995-05-01), Chiang et al.
Belik et al., "Reaction of Buckminsterfullerene with orth-Quinodimethane: a New Access to Stable C.sub.60 Derivatives", Angew. Chem. Int. Ed. Engl. 1:78-80, 1993.
Chiang et al., "Efficient Synthesis of Polyhydroxylated Fullerene Derivatives via Hydrolysis of Polycyclosulfated Precursors", J. Org. Chem., 59:3960-3968, 1994.
Chiang et al., "Evidence of Hemiketals Incorporated in the Structure of Fullerols Derived from Aqueous Acid Chemistry", J. Am. Chem. Soc., 115:5453-5457, 1993.
Chiang et al., "Free Radical Scavenging Activity of Water-soluble Fullernols", J. Chem. Soc. Chem. Commun., 1283-1284, 1995.
Chiang et al., "Multi-hydroxy Additions onto C.sub.60 Fullerence Molecules", J. Chem. Soc. Chem. Commun., 1791-1793, 1992.
Chiang et al., "Versatile Nitronium Chemistry for C.sub.60 Fullerene Functionalization", J. Am. Chem. Soc., 114:10154-10157, 1992.
Friedman et al., "Inhibition of the HIV-1 Protease by Fullerence Derivatives: Model Building Studies and Experimental Verification", J. Am. Chem. Soc, 115:6506-6509, 1993.
Hirsch et al., "Globe-trotting Hydrogens on the Surface of the Fullerence Compound C.sub.60 H.sub.6 (N(CH.sub.2 CH.sub.2).sub.2 0).sub.6 ", Angew. Chem. Int. Ed. Engl. 30:1309-1310, 1991.
Hoke et al., "Reaction of Fullerenes and Benzyne", J. Org. Chem. 57:5069-5071, 1992.
Isaacs et al., "Improved Purification of C.sub.60 and Formation of .gamma. and .PI.-Homoaromatic Methano-Bridged Fullerenes by Reaction with Alkyl Diazoacetates", Helvetica Chimica Acta 76:1231-1250, 1993.
Juha et al., "Reactivity of Fullerenes with Chemically Generated Singlet Oxygen", J. Chem. Soc., Chem. Commun., 2437-2438, 1994.
Krusic et al., "Radical Reactions of C.sub.60 ", Science 254:1183-1185, 1991.
Li et al., "C.sub.60 Fullerol Formation Catalysed by Quaternary Ammonium Hydroxides", J. Chem. Soc., Chem. Commun. 1784-1785, 1993.
Paulus et al., "Diethyl Methano-C.sub.60 -fullerene-61,61-dicarboxylate Chloroform Solvate at 193K, C.sub.60 C(CO.sub.2 C.sub.2 H.sub.5).sub.2 CHCI.sub.3 ", Acta Cryst, C51:143-146, 1995.
Prato et al., "[3+2] and [4+2] Cycloadditions of C.sub.60 ", J. Am. Chem. Soc. 115:1594-1595, 1993.
Shu et al., "Reaction of [80]Fullerene with 1-(4-Methoxyphenyl)-1-(trimethylsilyloxy)ethylene", J. Chem. Commun. 367-368, 1995.
Roy et al., "NO.sub.2 Adducts of C.sub.60 : Synthesis of Polynitro-Polyhydroxy Fullerenes", J. Chem. Soc., Chem. Commun. 275-276, 1994.
Balch et al., "Supramolecular Aggregation of an (90 .sup.2 -C.sub.60) Iridium Complex Involving Phenyl Chelation of the Fullerene", J. Am. Chem. Soc. 114:5455-5457, 1992.
Suzuki et al., "Systematic Inflation of Buckminsterfullerene C.sub.60 : Synthesis of Diphenyl Fulleriods C.sub.61 to C.sub.66 ", Science 254:1186-1188, 1991.
Taliani et al., "Light-induced Oxygen Incision of C.sub.60 ", J. Chem. Soc. Chem. Commun., 220-222, 1993.
Tokuyama et al. "Photoinduced Biochemical Activity of Fullerene Carboxylic Acid", J. Am. Chem. Soc. 115:7918-7919, 1993.
Tsuda et al, "Addition Reaction of Benzyne to C.sub.60 ", Chemistry Letters 2333-2334, 1992.
Wilson et al., "A New Reaction of Fullerenes: [2+2] Photocycloaddition of Enones", J. Am. Chem. Soc. 115:8495-8496, 1993.
Balch et al., "Supramolecular Aggregation of an (529 .sup.2 -C.sub.60) Iridium Complex Involving Phenyl Chelation of the Fullerene", J. Am. Chem. Soc. 114:5455-5457, 1992.
Chiang et al., "Pharmacology", Chemical Abstracts vol. 122, No. 23, Jun. 5, 1995, Abstract No. 281924.
Chiang et al., "Pharmacology", Chemical Abstracts vol. 124, No. 9, Feb. 26, 1996, Abstract No. 106531.
Chiang, et al., "Free-Radical Scavenging Effect of Water-Soluble [60] Fullerenols in Whole Blood . . . ", Proc.Electrochem.Soc. 95-10, 699 (1995).
Huang, et al., "Antiproliferative Effect of Polyhydroxylated C.sub.60 on Vascular Smooth Muscle Cells", Proc.Electrochem.Soc. 96-10, 403 (1996).

Affiliated with

Also associated with

Rating

Polyorganofullerenes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyorganofullerenes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyorganofullerenes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-366793