Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-11-07
2006-11-07
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07132393
ABSTRACT:
Improved transporter compositions effective for detecting or killing cells in acidic areas of tumors are described. Each composition includes a transporter peptide which at pH 7.2 and above is poly-anionic and so repels from cells in normal tissues, but at lower pH in hypoxic areas of tumors the transporter peptide converts to a non-ionic lipophilic form which transports across membranes of cells. Each composition also includes a cargo component which can be pulled across cell membranes by the transporter peptide and which is effective for detecting or killing cells into which the transporter composition has entered.
REFERENCES:
patent: 6030941 (2000-02-01), Summerton et al.
Jahde, Volk, Atema, Smets, Glusenkamp, Rajewsky (1992) Cancer Research 52, 6209-6215).
Bernard, Krenning, Breeman, Rolleman, Bakker, Visser, Macke, de Jong, Journal of Nuclear Medicine 38, 1929 (1997).
Garcia-Garayoa, Blauenstein, Bruehlmrier, Blanc, Iterbeke, Conrath, Tourwe & Schubiger (2002), The Journal of Nuclear Medicine 43, 374-383.
Prescott, Charles, Poulson, Page, Thrall, Vujaskovic, & Dewhirst (2000) Clinical Cancer Research 6, 2501-2505.
Kozin, Shkarin, & Gerweck (2001) Cancer Research 61, 4740-4743.
Kuin, Smets, Volk, Paans, Adams, Atema, Jahde, Maas, Rajewsky, & Visser (1994) Cancer Research 54, 3785-3792.
Campell Bruce R.
Friedman Lori M.
Gene Tools. LLC
Gudibande Satyanarayana R.
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