Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1989-10-23
1991-05-28
Lone, Werren B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568810, 568831, 568832, 568833, C07C 3512, C07C 2978
Patent
active
050196588
ABSTRACT:
The instant invention is an improvement in the method of producing optically pure sterioisomers from a racemic mixture. The method is based on the well-known fact that a supersaturated solution or melt of the racemic mixture can be seeded with just the crystals of the desired stereoisomer, which will then crystallize out selectively, leaving the undesired stereoisomer behind in the liquid mother liquor. The desired isomer, in crystaline form, can then be separated by simple liquid/solid separation from the undesired isomer remaining behind in the mother liquor. In the conventional method, supersaturation is achieved by careful cooling of a saturated solution or melt. In the present invention, supersaturation is achieved by increasing the ambient pressure over the saturated solution or melt of the racemic mixture, and relying on the fact that the melting temperature of a substance increases with increasing pressure, provided there is an increase in molar volume when the substance melts.
REFERENCES:
patent: 3053880 (1962-09-01), Dale
patent: 3943181 (1976-03-01), Fleisher et al.
patent: 4011270 (1977-03-01), Carrington
patent: 4418225 (1983-11-01), House
Kobe Steel Limited
Lone Werren B.
LandOfFree
Separation of pure optical stereoisomers by pressure crystalliza does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Separation of pure optical stereoisomers by pressure crystalliza, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Separation of pure optical stereoisomers by pressure crystalliza will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-36654