Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-04-09
2000-04-04
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 243, 536 2431, 536 2433, 435 6, 435 911, 435325, 435375, C07H 2104, C12N 1585, C12N 1586, C12Q 168
Patent
active
06046321&
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-i1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G-alpha-i1. Methods of using these compounds for modulation of G-alpha-i1 expression and for treatment of diseases associated with expression of G-alpha-i1 are provided.
REFERENCES:
patent: 5149797 (1992-09-01), Pederson
patent: 5639612 (1997-06-01), Mitsuhashi et al.
patent: 5770713 (1998-06-01), Imbach
patent: 5789573 (1998-08-01), Baker
patent: 5856462 (1999-01-01), Agrawal
Andrea D. Branch, A good antisense molecule is hard to find, TIBS, 47-48, Feb. 1998.
Trisha Gura, Antisense Has Growing Pains, Science, pp. 575-577, Oct. 1995.
Stanley Crooke, Antisense '97: A roundtable on the state of the industry, Nature Biotechnology, p. 522, Jun. 1997.
Stanley Crooke, Antisense Research and Applications, Chapter 1, Basic Principles of Antisense Therapeutics, Springer-Verlag Press, Berlin, Heidelberg, New York, p. 3, Jul. 1998.
Hamm, The many faces of G protein signaling, J. Biol. Chem., 1998, 273:669-672.
Redmond, Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells, Arterioscler. Thromb. Vasc. Biol., 1998, 18:75-83.
Schmidt, Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma, Hepatology, 1997, 26:1189-1194.
Svoboda, Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussin-toxin treatment, Biochem. J., 1996, 314:761-768.
Wise, Interactions of the alpha2A-adrenoceptor with multiple Gi-family G- proteins: studies with pertussis toxin-resistant G-protein mutants [published erratum appears in Biochem J 1997 May 1;323 (Pt 3):864], Biochem. J., 1997, 321:721-728.
Elliott George C.
Epps Janet
Isis Pharmaceuticals , Inc.
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