Methods of assaying receptor activity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007300, C435S288700, C436S172000, C436S042000, C436S501000

Reexamination Certificate

active

07138240

ABSTRACT:
Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process.

REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4219335 (1980-08-01), Ebersole
patent: 4324633 (1982-04-01), Lovejoy
patent: 4341761 (1982-07-01), Ganfield et al.
patent: 4342566 (1982-08-01), Theofilopoulos et al.
patent: 4399121 (1983-08-01), Albarella et al.
patent: 4426330 (1984-01-01), Sears
patent: 4427783 (1984-01-01), Newman et al.
patent: 4444887 (1984-04-01), Hoffmann
patent: 4451570 (1984-05-01), Royston et al.
patent: 4466917 (1984-08-01), Nussenzweig et al.
patent: 4472500 (1984-09-01), Milstein et al.
patent: 4491632 (1985-01-01), Wands et al.
patent: 4493795 (1985-01-01), Nestor, Jr. et al.
patent: 4493890 (1985-01-01), Morris
patent: 4534899 (1985-08-01), Sears
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4908773 (1990-03-01), Pantoliano et al.
patent: 4981784 (1991-01-01), Evans et al.
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5264221 (1993-11-01), Tagawa et al.
patent: 5284746 (1994-02-01), Sledziewski et al.
patent: 5324633 (1994-06-01), Fodor et al.
patent: 5352660 (1994-10-01), Pawson
patent: 5366889 (1994-11-01), MacDonald et al.
patent: 5462856 (1995-10-01), Lerner et al.
patent: 5468854 (1995-11-01), McCabe et al.
patent: 5482835 (1996-01-01), King et al.
patent: 5491084 (1996-02-01), Chalfie et al.
patent: 5522896 (1996-06-01), Prescott
patent: 5532157 (1996-07-01), Fink
patent: 5539082 (1996-07-01), Nielsen et al.
patent: 5541309 (1996-07-01), Prasher
patent: 5569824 (1996-10-01), Donehower et al.
patent: 5569827 (1996-10-01), Kessous-Elbaz et al.
patent: 5574656 (1996-11-01), Agrafiotis et al.
patent: 5575997 (1996-11-01), Leung et al.
patent: 5576436 (1996-11-01), McCabe et al.
patent: 5578079 (1996-11-01), Kamel et al.
patent: 5582834 (1996-12-01), Leung et al.
patent: 5591618 (1997-01-01), Chantry et al.
patent: 5597699 (1997-01-01), Lanzara
patent: 5602240 (1997-02-01), DeMesmaeker et al.
patent: 5625048 (1997-04-01), Tsien et al.
patent: 5627039 (1997-05-01), Pereira-Smith et al.
patent: 5658783 (1997-08-01), Grandy et al.
patent: 5661184 (1997-08-01), Helton et al.
patent: 5665710 (1997-09-01), Rahman et al.
patent: 5670113 (1997-09-01), Akong et al.
patent: 5684711 (1997-11-01), Agrafiotis et al.
patent: 5700673 (1997-12-01), McElroy et al.
patent: 5705335 (1998-01-01), Hendry
patent: 5714331 (1998-02-01), Buchardt et al.
patent: 5719262 (1998-02-01), Buchardt et al.
patent: 5744313 (1998-04-01), Williams et al.
patent: 5767337 (1998-06-01), Roses et al.
patent: 5770176 (1998-06-01), Nargessi
patent: 5777079 (1998-07-01), Tsien et al.
patent: 5804387 (1998-09-01), Cormack et al.
patent: 5821067 (1998-10-01), Grandy et al.
patent: 5854004 (1998-12-01), Czernilofsky et al.
patent: 5856111 (1999-01-01), Ullrich et al.
patent: 5864488 (1999-01-01), Isaacs et al.
patent: 5874219 (1999-02-01), Rava et al.
patent: 5882944 (1999-03-01), Sadée
patent: 5912122 (1999-06-01), Daggett et al.
patent: 5912137 (1999-06-01), Tsien et al.
patent: 5912138 (1999-06-01), Tonks et al.
patent: 5919646 (1999-07-01), Okun et al.
patent: 5958713 (1999-09-01), Thastrup et al.
patent: 5968750 (1999-10-01), Zolotukhin et al.
patent: 5972629 (1999-10-01), Niman
patent: 5972639 (1999-10-01), Parandoosh
patent: 5987390 (1999-11-01), Ladunga
patent: 5989835 (1999-11-01), Dunlay et al.
patent: 5998204 (1999-12-01), Tsien et al.
patent: 6007986 (1999-12-01), Sadée
patent: 6017496 (2000-01-01), Nova et al.
patent: RE36547 (2000-02-01), Crain et al.
patent: 6025129 (2000-02-01), Nova et al.
patent: 6027890 (2000-02-01), Ness et al.
patent: 6028175 (2000-02-01), Grandy et al.
patent: 6051386 (2000-04-01), Lerner et al.
patent: 6057114 (2000-05-01), Akong et al.
patent: 6066476 (2000-05-01), Tsien et al.
patent: 6087115 (2000-07-01), Gershengorn et al.
patent: 6096756 (2000-08-01), Crain et al.
patent: 6100026 (2000-08-01), Nova et al.
patent: 6100042 (2000-08-01), Fowlkes et al.
patent: 6103492 (2000-08-01), Yu
patent: 6107324 (2000-08-01), Behan et al.
patent: 6124102 (2000-09-01), Fodor et al.
patent: 6127133 (2000-10-01), Akong et al.
patent: 6140509 (2000-10-01), Behan et al.
patent: 6150393 (2000-11-01), Behan et al.
patent: 6255059 (2001-07-01), Klein et al.
patent: WO88/03168 (1988-05-01), None
patent: WO94/16684 (1994-08-01), None
patent: WO95/21191 (1995-08-01), None
patent: WO96/23810 (1996-08-01), None
patent: WO96/23898 (1996-08-01), None
patent: WO96/27027 (1996-09-01), None
patent: WO96/27675 (1996-09-01), None
patent: WO96/40062 (1996-12-01), None
patent: WO97/11091 (1997-03-01), None
patent: WO98/12310 (1998-03-01), None
patent: WO98/44350 (1998-10-01), None
patent: WO98/55635 (1998-12-01), None
patent: WO99/66324 (1999-12-01), None
patent: WO00/12704 (2000-03-01), None
Goodman, O., et al., “β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-Adrenergic receptor”,Nature, 383(3):447-450, 1996.
Heim, R., et al., “Wavelength mutations and posttranslational autoxidation of green fluorescent protein”,Proc. Natl. Acad. Sci., USA, [Biochemistry] 91(26): 12501-12504, 1994.
McConalogue, K, et al., “Cellular and Subcellular Localization of G-Protein Receptor Kinases, Arrestins and G-Proteins: Implications for Receptor Regulation”,Gastroenterology, 110(4): 1 Supplement:A1098 AGA Abstracts, 1996.
Prasher, D. C., et al., “Primary structure of theAequorea victoriagreen-fluorescent protein,”Gene, [Elsevier] 111(2): 229-233, 1992.
Zuckerman, R. and Cheasty, J. E., “Sites of arrestin action during the quench phenomenon in retinal rods”,Febs. Let., [Elsevier] 238(2): 379-384, 1988.
Atlas, D., et al., Probing of β-adrenergic receptors by novel fluorescent β-adrenergic blockers,Proceedings of the National Academy of Sciences, vol. 74, No. 12, Dec. 1977, pp. 5290-5294, Proc. natl. Acad. Sci, USA.
Angers, S., et al., Detection of β2-Adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET),Proceedings of the National Academy of Sciences, vol. 97, No. 7, Mar. 28, 2000, pp. 3684-3689, Proc. Natl Acad. Sci, USA.
Barak, L.S., et al., Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus, published Dec. 26, 2000,Proc. Natl. Acad. Sci USA Online, andProceedings of the National Academy of Sciences, vol. 98, No. 1, Jan. 2, 2001, pp. 93-98.
Barak, L.S., et al., Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and β-arrestin 2 during Homologous Desensitization of the Substance P Receptor,Journal of Biological Chemistry, vol. 274, No. 11, Mar. 12, 1999, pp. 7565-7569, The American Society for Biochemistry and Molecular Biology, Inc., USA.
Barak, L.S., et al., Characterization of a Green Fluorescent Protein Conjugated Beta2-Adrenergic Receptor,Molecular Biology of the Cell(supplement), Abstract #2484, vol. 7, p. 427a (Dec. 1996).
Bardram, L., et al., Processing-Independent Radioimmunoanalysis: A General Analytical Principle Applied to Progastrin and Its Products,Anal Biochem,vol. 175, pp. 537-543, 1988, Academic Press, Inc.
Benovic, J.L., et al.,Regulation of Adenylyl Cyclase-Coupled β-Adrenergic Receptors, Annual Review Cell Biology, vol. 4, pp. 405-428, 1988, Annual Reviews, Inc.
Bohn, Laura M., et al., Enhanced Morphine Analgesia in Mice lacking β-Arrestin 2,Science, (Washington, D.C.), vol. 286, No. 5449, Dec. 24, 1999, pp. 2495-2498.
Brady, III, C.E., Secretin Provocation Test in the Diagnosis of Zollinger-Ellison Syndrome,The American Journal of Gastroenterology, vol. 86, pp. 129-134, Feb. 1991, USA.
Bugat, R., et al., Gast

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