Treatment of arteriosclerosis and xanthoma

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514370, 514510, A61K 31425, A61K 3121

Patent

active

057983755

ABSTRACT:
A combination of one or more HMG-CoA reductase inhibitors (for example pravastatin, lovastatin, simvastatin, fluvastatin, rivastatin or atorvastatin) with one or more insulin sensitizers (for example troglitazone, pioglitazone, englitazone, BRL-49653, ine-2,4-dione, dine-2,4-dione or its hydrochloride, benzyllthiazolidine-2,4-dione) exhibits a synergistic effect and is significantly better at preventing and/or treating arteriosclerosis and/or xanthoma than is either of the components of the combination alone.

REFERENCES:
patent: 4287200 (1981-09-01), Kawamatsu et al.
patent: 4340605 (1982-07-01), Kawamatsu et al.
patent: 4346227 (1982-08-01), Terehara et al.
patent: 4438141 (1984-03-01), Kawamatsu et al.
patent: 4444779 (1984-04-01), Kawamatsu et al.
patent: 4448979 (1984-05-01), Terahara et al.
patent: 4461902 (1984-07-01), Kawamatsu et al.
patent: 4572912 (1986-02-01), Yoshioka et al.
patent: 4687777 (1987-08-01), Meguro et al.
patent: 4703052 (1987-10-01), Eggler et al.
patent: 4725610 (1988-02-01), Meguro et al.
patent: 4739073 (1988-04-01), Kathawala
patent: 4873255 (1989-10-01), Yoshioka et al.
patent: 4897393 (1990-01-01), Iijima et al.
patent: 4897405 (1990-01-01), Alessi et al.
patent: 4918091 (1990-04-01), Cantello et al.
patent: 4948900 (1990-08-01), Iijima et al.
patent: 5002953 (1991-03-01), Hindley
patent: 5006530 (1991-04-01), Angerbauer et al.
patent: 5061717 (1991-10-01), Clark et al.
patent: 5120754 (1992-06-01), Clark et al.
patent: 5132317 (1992-07-01), Cantello et al.
patent: 5169857 (1992-12-01), Angerbauer et al.
patent: 5194443 (1993-03-01), Hindley
patent: 5223522 (1993-06-01), Clark et al.
patent: 5232925 (1993-08-01), Hindley
patent: 5260445 (1993-11-01), Hindley
patent: 5273995 (1993-12-01), Roth
patent: 5401746 (1995-03-01), Angerbauer et al.
Yoshio Watanabe et al, "Preventive effect of pravastatin sodium, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on coronary atherosclerosis and xanthoma in WHHL rabbits", Biochimica et Biophysica Acta, 960 (1988), pp. 294-302.
Masashi Shiomi et al, "Suppression of established atherosclerosis and xanthomas in mature WHHL rabbits by keeping their serum cholesterol levls extremely low", Atherosclerosis, 83 (1990), pp. 69-80.
J. Otto et al, "Lovastatin inhibits diet induced atherosclerosis in F1B Golden Syrian hamsters", Atherosclerosis, 114 (1995), pp. 19-28.
T.A. Kotchen, "Attenuation of Experimental Hypertension with Agents That Increase Insulin Sensitivity", DRUG DEVELOPMENT RES., vol. 32, 1994, pp. 100-103, XP000603648.
J. Clinical Therapeutics & Medicines, 9, Suppl. 3, 19-37, (1993), English translation attached.
J. Clinical Therapeutics & Medicines, 9, Suppl. 3, 151-164, (1993), English translation attached.
Clinic All-round 43, 2615-2621 (1994), English translation attached.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Treatment of arteriosclerosis and xanthoma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of arteriosclerosis and xanthoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of arteriosclerosis and xanthoma will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-36647

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.