Substituted 3-(aminoalklamino)-1,2-benzisoxazoles and related co

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514254, 514321, 544238, 544239, 544240, 544295, 544357, 544360, 544364, 544368, 544363, 544371, 546198, A61K 3142, C07D41304, C07D41312, C07D41314

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060462035

ABSTRACT:
This application relates to compounds of the formula ##STR1## wherein R.sup.1,X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.

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Yevich et al., Synthesis . . . of Piperazine Derivatives as Potential Antipsychotic Agents, J. Med. Chem., 29 (3), pp. 359-369, 1986.

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