Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-11-28
2006-11-28
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S388000, C548S161000, C548S163000, C548S307400, C548S308400, C548S309100
Reexamination Certificate
active
07141594
ABSTRACT:
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
REFERENCES:
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4595407 (1986-06-01), Carter
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4634465 (1987-01-01), Ehrenfreund et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: H725 (1990-01-01), Gordon
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5278148 (1994-01-01), Branca et al.
patent: 5776971 (1998-07-01), Getman et al.
patent: 5972989 (1999-10-01), Getman et al.
patent: 6063795 (2000-05-01), Getman et al.
patent: 6172101 (2001-01-01), Getman et al.
patent: 6214861 (2001-04-01), Getman et al.
patent: 6407134 (2002-06-01), Getman et al.
patent: 6673822 (2004-01-01), Getman et al.
patent: A-79823/87 (1988-04-01), None
patent: 0 393 445 (1990-10-01), None
patent: 0 104 041 (1984-03-01), None
patent: 0 114 993 (1984-08-01), None
patent: 0 172 347 (1986-02-01), None
patent: 0 223 437 (1987-05-01), None
patent: 0 264 795 (1988-04-01), None
patent: 0 264 795 (1988-04-01), None
patent: 0 337 714 (1989-10-01), None
patent: 0 342 541 (1989-11-01), None
patent: 0 346 847 (1989-12-01), None
patent: 0 356 223 (1990-02-01), None
patent: 0 389 898 (1990-10-01), None
patent: 0 393 457 (1990-10-01), None
patent: 0 402 646 (1990-12-01), None
patent: 0 468 641 (1992-01-01), None
patent: 2184730 (1987-07-01), None
patent: 2200115 (1988-07-01), None
patent: 2209752 (1989-05-01), None
patent: WO 84/03044 (1984-08-01), None
patent: WO 92/00750 (1992-01-01), None
patent: WO 92/08699 (1992-05-01), None
patent: WO 93/13066 (1993-07-01), None
patent: PCT/US93/08458 (1994-03-01), None
patent: WO 94/04492 (1994-03-01), None
patent: WO 94/05639 (1994-03-01), None
patent: WO 94/10133 (1994-05-01), None
patent: WO 94/10134 (1994-05-01), None
patent: WO 95/06030 (1995-03-01), None
patent: WO 95/33464 (1995-12-01), None
Roberts et al., “Rational Design of Peptide-Based HIV Proteinase Inhibitors”, Science, 248, 358-361, (1990).
Erickson et al., “Design, Activity, and 2.8 Å Crystal Structure of a C2Symmetric Inhibitor Complexed to HIV-1 Protease”, Science, 249, 527-533 (1990).
Pearle et al., Nature, International Weekly Journal of Science, vol. 328, No. 6130, p. 482, Aug. 6-12, (1987).
Martin, “Ro 31-8959/003”,Drugs of the Future, 16 (3), 210-212 (1991).
Meek et al., “Inhibiton of HIV-1 Protease in Infected T-lymphocytes by Synthetic Peptide Analogues”, Nature, vol. 343, pp. 90-92 (1990).
McQuade, “A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation”, Science, vol. 247, 454-456 (1990).
Rich et al., “Design of Protease Inhibitors”, Peptide Inhibitors of Proteases, 511-520, 1983.
Rosenberg et al., “Novel Renin Inhibitors Containing Analogues of Statine Retro-Inverted at the C-Termini: Specificity at the P2Histidine Site”, J. Med. Chem., 30, 1224-1228 (1987).
Fittkau, α-Aminochloromethylketone aus Aminosäuren and Peptiden als substratanaloge Inhibitoren der Leucinaminopeptidase, Journal f. Prakt. Chemie., Band 315, Heft 6, S.1037-1044 (1973).
Hirsch et al. “Therapy for Human Immunodeficiency Virus Infection”, New England Journal of Medicine, vol. 328, No. 23, 1686-1695 (1993).
E.E. Gilbert, “Recent Developments in Preparative Sulfonation and Sulfation”, Synthesis, International Journal of Methods in Synthetic Organic Chemistry, No. 1: Sep. (1969).
Mitsuya et al., “Inhibition of thein vitroInfectivity and Cytopathic Effect of Human T-lymphotrophic Virus Type III/Lymphadenopathy-Associated Cirus (HTLV-III/LAV) by 2′,3′-Dideoxynulceosides”, Prod. Natl. Acad. Sci. USA, vol. 83, 1911-15 Mar. (1986).
Silcox et al., “Benzodioxoles, Napthodioxins and Dibenzodioxepins”, J. Heterocycl. Chem., 4, 166-67 (1967).
Cabiddu et al., “A Convenient Method for the Synthesis of 1,3-Benzoxathioles”, Synthesis, 797-798 (1976).
International Search Report dated Jul. 25, 1996 for application PCT/US96/02683.
Ncube et al., “Generation and Reactions of 2-Lithio-2-Substituted-1-3-Benzodithioles: New, Convenient Acyl Carbanion Equivalents”, Tetrahedron Letters No. 26, 2345-2348 (1978).
Ncube et al., “A Convenient Synthesis of 2-Alkyl- and 2-Aryl-1,3-Benzodithioles”, Tetrahedron Letters No. 3, 255-256 (1977).
Cole et al., “An Improved Method for the Synthesis of 2,2-Disubstitued and 2-Monosubstituted 1,3-Benzodioxoles”, Aust. J. Chem., 33, 675-80 (1980).
Brown David L.
DeCrescenzo Gary A.
Devadas Balekudru
Freskos John N.
Getman Daniel P.
Banner & Witcoff , Ltd.
G. D. Searle & Co.
Stockton Laura L.
LandOfFree
Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3653941