Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1997-05-27
2000-04-04
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
562 8, 562 24, A61K 31685, C07F 930, C07F 922
Patent
active
060461802
ABSTRACT:
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
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Jackson Paul F.
Maclin Keith M.
Slusher Barbara S.
Tays Kevin L.
Guilford Pharmaceuticals Inc.
Juneau Todd L.
Nath Gary M.
Rotman Alan L.
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