Aryloxyphenyl and arylsulfanylphenyl derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C514S255030, C514S089000, C514S277000, C514S317000, C544S231000, C544S337000, C544S394000, C546S016000, C546S022000, C546S236000, C546S237000, C546S238000, C546S341000

Reexamination Certificate

active

07067501

ABSTRACT:
The invention provides compounds of the formulawherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors.

REFERENCES:
patent: 10-152470 (1998-06-01), None
patent: WO 97/20533 (1997-06-01), None
patent: WO 98/17651 (1998-04-01), None
patent: 2005018676 (2005-03-01), None
Smith et al. Bioorganic & Medicinal Chemistry Letters, vol. 14, p. 4027-4030 (Aug. 2, 2004).
Javitt et al., 1994, Amelioration of Negative Symptoms in Schizophrenia by Glycine,Am. J. Psychiatry,151:1234-1236.
Kiritsy et al., 1978, Synthesis and Quantitative Structure-Activity Relationships of Some Antibacterial 3-Formylrifamycin SV N-(4-substituted phenyl)piperazinoacethydrazonesJ. of Medicinal Chem.,21:1301-1307.
Leiderman et al., 1996, Preliminary Investigation of High-Dose Oral Glycine on Serum Levels and Negative Symptoms in Schizophrenia: An Open-Label TrialBiol. Psychiatry, 39:213-215.
Rison et al., 1995, Long-term Potentiation and N-Methyl-D-aspartate Receptors: Foundations of Memory and Neurologic Disease?Neurosci. Biobehav. Rev., 19:533-552.
Truong et al., 1988, Glycine Involvement in DDT-Induced MyoclonusMovement Disorders,3:77-87.
Yaksh, 1989, Behavioral and Autonomic Correlates of the Tactile Evoked Allodynia Produced by Spinal Glycine Inhibition: Effects of Modulatory Receptor Systems and Excitatory Amino Acid AntagonistsPain, 37:111-123.

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