Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...
Reexamination Certificate
2006-06-20
2006-06-20
Swartz, Rodney P (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds bacterium or component thereof or substance produced...
C424S130100, C424S139100, C424S184100, C424S185100, C424S190100, C424S234100, C435S243000, C530S300000, C530S350000
Reexamination Certificate
active
07063846
ABSTRACT:
Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins ofE. chaffeensisand variants thereof, referred to hereinafter as the “OMP proteins”, a group of outer membrane proteins ofE. canisand variants thereof referred to hereinafter as the “P30F proteins”, and antibodies to the OMP proteins and the P30F proteins. The OMP proteins ofE. chaffeensisencompass OMP-1, OMP-1A, OMP1-B, OMP-1C, OMP1-D, OMP1-E, OMP1-F, OMP1-H, OMP-1R, OMP-1S, OMP-1T, OMP-1U, OMP-1V, OMP-1W, OMP-1X, OMP-1Y and OMP-1Z. The P30F proteins ofE. canisencompass P30, P30a, P30-1, P30-2, P30-3, P30-4, P30-5, P30-6, P30-7, P30-8, P30-9, P30-10, P30-11, and P30-12. Isolated polynucleotides that encode theE. chaffeensisOMP proteins and isolated polynucleotides that encode theE. canisP30F protein are also provided. The present invention also relates to kits containing reagents for diagnosing human ehrlichiosis and canine ehrlichiosis, and to immunogenic compositions containing one or more OMP proteins or P30F proteins.
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Ohashi Norio
Rikihisa Yasuko
Calfee Halter & Griswold
Swartz Rodney P
The Ohio State University Research Foundation
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