Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-10-17
2006-10-17
Chin, Christopher L. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007210, C435S040500, C435S040520, C435S960000, C436S503000, C436S087000, C530S389300
Reexamination Certificate
active
07122322
ABSTRACT:
A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the presence of a purified and isolated endometriotic haptoglobin designated ENDO-I and functional analogs thereof. A therapeutic for treating endometriosis by modulating the expression of a purified and isolated endometriotic haptoglobin designated ENDO-I and functional analogs thereof and a pharmaceutically acceptable carrier.
REFERENCES:
Nothnick et al., 1994. Detection of a unique 32-kd protein in the peritoneal fluid of women with endometriosis. Fertility and Sterility 61: 288-293.
Hoffman et al., 1996. A haptoglobin-like glycoprotein is produced by implantation-stage rabbit endometrium. Biology of Reproduction 55: 176-184.
Dunselman et al., 1988. The acute-phase response in endometriosis of women. J. Reprod. Fert. 83: 803-808.
Olson et al., 1997. Specific expression of haptoglobin mRNA in implantation-stage rabbit uterine epithelium. Journal of Endocrinology 152: 69-80.
Boe et al., 1994. Determination of haptoglobin expression in IL-6 treated HepG2 cells by an ELISA and by RNA hybridization—evaluation of a quantitative method to measure IL-6. J. Immunological Methods 171: 157-167.
Wagner et al., 1996. Haptoglobin phenotyping by newly developed monoclonal antibodies. J. Immunology 156: 1989-1996.
Chin Christopher L.
Grun James L.
Kohn Kenneth I.
Kohn & Associates PLLC
The Curators of the University of Missouri
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