Process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thia

Details Process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thia Process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thia

1998-12-18

2000-03-07

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D285125

Patent

active

060342455

ABSTRACT:
The present invention provides a process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. The process includes the steps of reacting methyidithiocarbazinate with trifluoroacetic acid, in the absence of phosphorus trichloride, to form a mixture of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole and 2,5-bis-(methylthio)-1,3,4-thiadiazole. Further, the process of the present invention includes selectively removing the 2,5-bis-(methylthio)-1,3,4-thiadiazole by acidifying the reaction mixture, and then separating the aqueous and organic phases.

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patent: 5147443 (1992-09-01), Diehr et al.
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Gyoefi and Csavassy, Acta Chimica Academiae Scientiarum Hungaricae, Tomus 82 (1): 91-97, (month unavailable) 1974.

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