Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2006-10-03
2006-10-03
Duffy, Patricia A. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S190100, C424S192100, C530S300000, C530S350000, C530S402000, C530S403000
Reexamination Certificate
active
07115271
ABSTRACT:
A novel surface exposed protein ofHaemophilus influenzaeor relatedHaemophilusspecies is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates ofH. influenzaestudied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene fromH. influenzaeinE. coliis described as well as the nucleotide sequence and the deduced amino acid sequence.
REFERENCES:
patent: 3800798 (1974-04-01), Winkler
patent: 3995018 (1976-11-01), Sjöquist
patent: 5888517 (1999-03-01), Forsgren
patent: 6139846 (2000-10-01), Forsgren
patent: RE37919 (2002-12-01), Kronenber et al.
patent: 6680057 (2004-01-01), Yao et al.
patent: 0 131 142 (1985-01-01), None
patent: 0 200 909 (1986-02-01), None
patent: 0 281 673 (1988-09-01), None
patent: 0 320 289 (1989-06-01), None
patent: 87/05631 (1987-09-01), None
Gomi et al, (The Journal of Immunology, 144:4046-4052, May 15, 1990).
Sambrook et al, (Molecular Cloning, Cold Spring Harbor Laboratory Press, 1989, pp. 17.1-17.44).
Goding (in “Monocolonal Antibodies”, Academic Press Inc., London, 1983.
Campbell (in “Monoclonal Antibody Technology”, Elsevier Science Publishing Company, Inc. New York, NY, 1986, pp. 1-32).
(Rudinger et al, in “Peptide Hormones”, edited by Parsons, J.A., University Park Press, Jun. 1976, p. 6.
Burgess et al., The Journal of Cell Biology, 111:2129-2138, 1990.
Lazar et al., Molecular and Cellular Biology, 8(3):1247-1252, 1988.
Larson et al (Archives of Biochemistry and Biophysics, 260(2):577-584, 1988).
SwissProt Database Accession No. P09394, created Mar. 1, 1989.
Munson et al (The Journal of Bacteriology, 175(14):4569-4571, Jul. 1993).
Dashefsky et al., “Safety, Tolerability and Immunogenicity of Concurrent Administration ofHaemophilus influenzaType b Conjugate Vaccine (Meningococcal Protein Conjugate) With Either Measles-Mumps-Rubells Vaccine or Diphtheria-Tetanus-Pertussis and Oral Poliovirus Vaccines in 14- to 23-Month-Old Infants”, Pediatrics Supplement, 85(4):682-689, part 2, (1990).
Janson et al, “Protein D, the Immunoglobin D-Binding Protein ofHaemophilus infuenzae, Is a Lipoprotein”, Infection and Immunity 60:1336-1342, (1992).
Murphy et al, “NontypeableHaemophilus Influenzae: A review of Clinical Aspects, Surface Antigens, and the Human Immune Response to Infection”, Review of Infectious Diseases, 9:1-15, (1987).
Munson, Jr. et al., “Purification and Comparison of Outer Membrane Protein P2 fromHaemophilus influemzaeType b Isolates”, J. Chem Invest., 72:677-684, (1983).
Munson, Jr. et al., Purification and Partial Chacterization of Outer Membrane Proteins P5 and p6 fromHaemophilus influenzaeType b Infection and Immunity 49:544-549, (1985).
Kimura et al, “A Minor High-Molecular-Weight Outer Membrane Protein ofHaemophilus influenzaeType b is a Protective Antigen”, Infection and Immunity, 47(1):253-259, (1985).
Murphy et al, “A Subtyping System for NontypableHaemophilus influenzaeBased on Outer-Membrane Proteins”, The Journal of Infectious Diseases, 147(5):838-846, (1983).
Weber et al, “The Realiability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis”, The Journal of Biological Chemistry, 244(16):4406-4412, (1969).
Clark-Curtiss et al, “Molecular Analysis of DNA and Construction of Genomic Libraries ofMycobacterium leprae”, Journal of Bacteriology, 161(3):1093-1102, (1985).
Shine et al., “The 3′-Terminal Sequence ofEschericia coli16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites”, Proc. Nat. Acad. Sci., U.S.A., 71(4):1342-1346, (1974).
Vlasuk et al, “Effect of Complete Removal of Basic Amino Acid Residues from the Signal Peptide on Secretion of Lipoprotein inEscherichia coli*”, The Journal of Biological Chemistry, 258(11):7141-7148, (1983).
Forsgren et al, “Many Bacterial Species Bind Human IgD”, The Journal of Immunology, 122(4):1468-1472, (1979).
Janson et al, “Protein D, an Immunoglobin D-Binding Protein ofHaemophilus influenzae: Cloning, Nucleotide Sequence, and Expression inEscherichia coli”, Infection and Immunity, 59(1):119-125, (1991).
Ruan et al, “Protein D ofHaemophilus influenzae: A Novel Bacterial Surface Protein with Affinity for Human IgD1”, The Journal of Immunology, 145(10):3379-3384, (1990).
Lenser et al, “Protection of Mice against the Lethal Effect of an Intraperitoneal Infection withHaemophilus(Actinobacillus)pleuropneumoniaeafter Vaccination with Capsular Proteins”, Veterinary Microbiology, 18(3-4):335-348, (1988).
Munson et al, “Protein D, a Putative Immunoglobulin D-Binding Protein Produced byHaemophilus influenzae, Is Glycerophosphodiester Phosphodiesterase”, Journal of Bacteriology, 175(14):4569-4571, (1993).
Larson et al, “Purification and Characterization of glpQ-Encoded Glycerophosphodiester Phosphodiesterase fromEscherichia coliK-121”, Archives of Biochemistry and Biophysics, 260(2):577-584, (1988).
Sasaki et al, “Protein D ofHaemophilus influenzaeIs Not a Universal Immunoglobulin D-Binding Protein”, Infection and Immunity, 61(7):3026-3031, (1993).
Fedorka-Crey et al, “Efficacy of a Cell Extract fromActinobacillus(Haemophilus)pleuropneumoniaeSerotype 1 against Diseases in Swine”, Infection and Immunity, 58(2):358-365, (1990).
Loeb et al, Pediatr. Infect. Dis. J., 8(1 suppl.)548-550.
Janson et al, Abstra. on Meet Am. Soc. Microbiol., 92:136, 1992.
Allen et al, “Molecular structure of mammalian neuropeotide Y: Analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue”, Proceedings of the National Academy of Sciences, 84:2532-2536 (1987).
Song et al., “The Gene Encoding Protein D (hpd) Is Highly Conserved amongHaemophilus influenzaeType b and nontypeable Strains”, Infection and Immunity, 63(2); 696-699 (1995).
Janson, et al., Limited Diversity of the Protein D Gene (hpd) among Encapsulated and NonencapsulatedHaemophilus infuenzaeStrains, Infection and Immunity, 61(11), pp. 4546-4552 (1993).
Anderson, et al. “Human adult immunogenicity of protein-coupled pneumococcal capsular antigens of serotypes prevalent in otitis media”, Infec. Dis. J. (1989).
Duim et al., “Sequence variation in the hpd gene of nonencapsulated Haemophilus influenzae isolated from patients with chronic bronchitis,” Gene vol. 191, pp. 57-60 (1997).
Lundstrom et al., “Stereospecific biding capacity of proteins on surfaces—simple mathematical models,” J. Theor. Biol. vol. 110, pp. 195-204 (1984).
Duffy Patricia A.
Finnegan Henderson Farabow Garrett & Dunner LLP
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