Compounds and methods for immunotherapy and immunodiagnosis of p

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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5303871, 536 231, 514 2, 435 4, 4241851, C07K 1400

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060342188

ABSTRACT:
Compounds and methods for treating and diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides or DNA molecules encoding such polypeptides are also provided. The inventive polypeptides may also be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.

REFERENCES:
Tubiana, M. J. Cancer Res Clin Oncol (Germany) 117 (4): 275-89, 1991.
Alkema et al., "Characterization and chromosomal localization of the human proto-oncogene BMI-1," Human Molecular Genetics 2(10):1597-1603, 1993.
Baxendale et al., "A cosmid contig and high resolution restriction map of the megabase region containing the Huntington's disease gene," Nature Genetics 4:181-186, 1993.
Bhargava et al., "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells," Proc. Natl. Acad. Sci. USA 90: 10260-10264, 1993.
Chen and Lim, "The Caenorhabditis elegans Small GTP-binding Protein RhoA Is Enriched in the Nerve Ring and Sensory Neurons during Larval Development," The Journal of Biological Chemsitry 269(51):32394-32404, 1994.
El-Shirbiny, "Prostate Specific Antigen," Advances in Clinical Chemistry 31:99-133, 1994.
Fleischmann et al., "Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd," Science 269:496-512, 1995.
Gerards et al., "Cloning and expression of a human pro(tea)some .beta.-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity," FEBS Letters 346:151-155, 1994.
Grant et al., "The molecular basis for alternative splicing of the CABP1 transcripts in Dictyostelium discoideum," Nucleic Acid Research 18(18):5457-5463, 1990.
Groffen et al., "Isolation of Human Oncogene Sequences (v-fes Homolog) from a Cosmid Library," Science 216:1136-1138, 1982.
Haarer et al., "Identification of MYO4, a second class V myosin gene in yeast," Journal of Cell Science 107:1055-1064, 1994.
Habu et al., "Structure and Regulated Expression of Kunitz Chymotrypsin Inhibitor Genes in Winged Bean [Psophocarpus tetragonolobus (L.) DC.]," J. Biochem. 111:249-258, 1992.
Heller et al., "Analysis of function and expression of the chick GPA recptor (GPAR.alpha.) suggests multiple roles in neuronal development," Development 121:2681-2693, 1995.
Holowachuk, "Isolation and Characterization of a cDNA Clone for the MHC Class II Chain RT1.D.sup.u .sub..beta. of the Diabetic BB Rat," Immunogenetics 22:665-671, 1985.
Jacquet et al., "Sequence analysis of a Dictyostelium discoideum gene coding for an active diydroorotate dehydrogenase in yeast," Biochimie 67(6): 583-588, 1995.
Johnston et al., "Complete Nucleotide Sequence of Saccharomyces cerevisiae Chromosome VIII," Science 265:2077-2082, 1994.
Jung et al., "Structural Characterization of the Rat Carboxypeptidase-E Gene," Molecular Endocrinology 5:1257-1268, 1991.
Matsuda et al., "ATP Synthase .gamma.-Subunit Gene and Tissue-specific Splicing," J. Biol. Chem. 268(33):24950-24958, 1993.
McAllister et al., "Molecular cloning of a serotonin receptor from human brain (5HT1E):A fifth 5HT1-like subtype," Proc. Natl. Acad. Sci. USA 89:5517-5521, 1992.
Osband and Ross, "Problems in the investigational study and clinical use of cancer immunotherapy," Immunology Today 11(6):193-195, 1990.
Rearden, "A New Lim Protein Containing An Autoepitope Homologous To Senescent Cell Antigen", Biochemical and Biophysical Research Communications 201(3):1124-1131, 1994.
Schuetz et al., "Isolation of a cDNA for HSF2:Evidence for two heat shock factor genes in humans," Proc. Natl. Acad. Sci. USA 88:6911-6915, 1991.
Sheldon and Kingston, "Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2," Genes & Development 7:1549-1558, 1993.
Weissbach et al., "Identification of a Human RasGAP-related Protein Containing Calmodulin-binding Motifs," J. Biol. Chem. 269(32):20517-20521, 1994.
Wilson et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans," Nature 368:32-38, 1994.
Yasuda et al., "Molecular evidence for a role of domestic ducks in the introduction of avian H3 influenza viruses to pigs in southern China, where the A/Hong Kong/68 (H3N2) strain emerged," Journal of General Virology 72(2007-2010), 1991.

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