Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-07-22
2000-04-04
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 4353201, 435325, 4353523, 4351723, 536 2431, 536 231, 530350, C07H 2104, C12N 1512, C12N 1563
Patent
active
06046027&
ABSTRACT:
The invention provides a human retinoid binding protein (RBPhu) and polynucleotides which identify and encode RBPhu. The invention also provides expression vectors, host cells, agonists, antibodies antagonists. The invention also provides methods for treating disorders associated with expression of RBPhu.
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Lin, C. C. et al., Differential Fluorescent Staining of Human Chromosomes with Daunomycin and Adriamycin-The D- Bands, Science, vol. 190, pp. 61-63, 1975.
Veerkamp, J.H., et al., "Structural and functional features of different types of cytoplasmic fatty acid-binding proteins", Biochimica et Biophysica Acta, 1081(1):1-24 (1991).
Napoli, J.L., "Retinoic acid biosynthesis and metabolism", The FASEB Journal, 10:993-1001 (1996).
Smith, W.C., et al., "A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter", EMBO Journal, 10:2223-2230 (1991). (GI 50548) (GI 50547).
Colantuoni, V., et al., "Cloning and Sequencing of a Full Length cDNA Corresponding to Human Cellular Retinol-Binding Protein", Biochemical and Biophysical Research Communications, 130(1):431-439 (1985). (GI 190948)(GI 190947).
Lotan, R., "Retinoids in cancer chemoprevention", The FASEB Journal, 10:1031-1039 (1996).
Boylan, J.F., et al., "Overexpression of the Cellular Retinoic Acid Binding Protein-I (CRABP-I) Results in a Reduction in Differentiation-specific Gene Expression in F9 Teratocarcinoma Cells", J Cell Biol, 112(5):965-979 (1991).
Orfanos, C.E., et al., "Current Use and Future Potential Role of Retinoids in Dermatology", Drugs,53(3):358-388 (1997).
Rosewicz, S., et al., "Retinoids: Effects on Growth, Differentiation, and Nuclear Receptor Expression in Human Pancreatic Carcinoma Cell Lines", Gastroenterology, 109:1646-1660 (1995).
La Vecchia, C., et al., "Adverse effects of preventive therapy in humans", IARC Sci Publ, 139:135-142 (1996).
Berkow, R., et al., The Merck Manual of Diagnosis and Therapy, Merck & Co., Rahway N.J. 959-960 (1992).
Smith, W.C., et al., (GI 50547) GenBank Sequence Database (Accession X60367), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 50548).
Colantuoni, V., et al., (GI 190947) GenBank Sequence Database (Accession M11433), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 190948).
Kane, C.D., et al., "A Simple Assay for Intracellular Lipid-binding Proteins Using Displacement of 1-Anilinonapththalene 8-Sulfonic Acid", Analytic Biochemistry, 233:197-204 (1996).
Veerkamp, J.H., et al., "Structural and functional features of different types of cytoplasmic fatty acid-binding proteins", Biochimica et Biophysica Acta, 1081(1):1-24 (1991).
Napoli, J.L., "Retinoic acid biosynthesis and metabolism", The FASEB Journal, 10:993-1001 (1996).
Smith, W.C., et al., "A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter", EMBO Journal, 10:2223-2230 (1991). (GI 50548) (GI 50547).
Colantuoni, V., et al., "Cloning and Sequencing of a Full Length cDNA Corresponding to Human Cellular Retinol-Binding Protein", Biochemical and Biophysical Research Communications, 130(1):431-439 (1985). (GI 190948)(GI 190947).
Lotan, R., "Retinoids in cancer chemoprevention", The FASEB Journal, 10:1031-1039 (1996).
Boylan, J.F., et al., "Overexpression of the Cellular Retinoic Acid Binding Protein-I (CRABP-I) Results in a Reduction in Differentiation-specific Gene Expression in F9 Teratocarcinoma Cells", J Cell Biol, 112(5):965-979 (1991).
Orfanos, C.E., et al., "Current Use and Future Potential Role of Retinoids in Dermatology", Drugs, 53(3):358-388 (1997).
Rosewicz, S., et al., "Retinoids: Effects on Growth, Differentiation, and Nuclear Receptor Expression in Human Pancreatic Carcinoma Cell Lines", Gastroenterology, 109:1646-1660 (1995).
La Vecchia, C., et al., "Adverse effects of preventive therapy in humans", IARC Sci Publ, 139:135-142 (1996).
Berkow, R., et al., The Merck Manual of Diagnosis and Therapy, Merck & Co., Rahway N.J. 959-960 (1992).
Smith, W.C., et al., (GI 50547) GenBank Sequence Database (Accession X60367), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 50548).
Colantuoni, V., et al., (GI 190947) GenBank Sequence Database (Accession M11433), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 190948).
Kane, C.D., et al., "A Simple Assay for Intracellular Lipid-binding Proteins Using Displacement of 1-Anilinonapththalene 8-Sulfonic Acid", Analytic Biochemistry, 233:197-204 (1996).
Bandman Olga
Guegler Karl J.
Shah Purvi
Basi Nirmal S.
Hutzell Paula K.
Incyte Pharmaceuticals Inc.
Muenzen Colette C.
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