Use of natural cyclodextrins and their derivatives for the solub

Details Use of natural cyclodextrins and their derivatives for the solub Use of natural cyclodextrins and their derivatives for the solub

1996-09-09

1998-08-25

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4241951, 514185, 514783, 536103, A61K 31715, A61K 31335, A61K 31365

Patent

active

057983429

ABSTRACT:
The invention relates to the use of natural cyclodextrins and their derivatives for the solubilization of platelet anti-aggregating agents from the family of Ginkgolides.
The cyclodextrins used comply with the formula: ##STR1## in which n is equal to 6, 7 or 8 and the R.sup.1, which can be the same or different, represent OH or SR.sup.2 with R.sup.2 representing a group derived from a monosaccharide or an oligosaccharide.
The Ginkgolide is preferably Ginkgolide B.

REFERENCES:
patent: 5180588 (1993-01-01), Shinmen et al.
patent: 5211953 (1993-05-01), Shinmen et al.
patent: 5240732 (1993-08-01), Ueda
patent: 5322688 (1994-06-01), Schwabe
patent: 5399348 (1995-03-01), Schwabe
patent: 5512286 (1996-04-01), Schwabe
Szejtli, J. "Medicinal Applications of Cyclodextrins", Medicinal Research Reviews, vol. 14(3): 353-386, (1994).

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