Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Reexamination Certificate
2006-10-10
2006-10-10
Parkin, Jeffrey S. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
C424S188100, C424S208100, C424S153100, C424S143100, C424S178100, C530S350000
Reexamination Certificate
active
07118751
ABSTRACT:
Vaccines that target one or more antigens to a cell surface receptor improve the antigen-specific humoral and cellular immune response. Antigen(s) linked to a domain that binds to a cell surface receptor are internalized, carrying antigen(s) into an intracellular compartment where the antigen(s) are digested into peptides and loaded onto MHC molecules. T cells specific for the peptide antigens are activated, leading to an enhanced immune response. The vaccine may comprise antigen(s) linked to a domain that binds at least one receptor or a DNA plasmid encoding antigen(s) linked to a domain that binds at least one receptor. A preferred embodiment of the invention targets HIV-1 env antigen to the CD40 receptor, resulting in delivery of antigen to CD40 positive cells, and selective activation of the CD40 receptor on cells presenting HIV-1 env antigens to T cells.
REFERENCES:
patent: 5521288 (1996-05-01), Linsley et al.
patent: 5540926 (1996-07-01), Aruffo et al.
patent: 5580773 (1996-12-01), Kang et al.
patent: 5658762 (1997-08-01), Zanetti et al.
patent: 5698679 (1997-12-01), Nemazee et al.
patent: 5945513 (1999-08-01), Aruffo et al.
patent: 5962406 (1999-10-01), Armitage et al.
patent: 5981724 (1999-11-01), Armitage et al.
patent: 6086875 (2000-07-01), Blumberg et al.
patent: 6113901 (2000-09-01), Bluestone et al.
Howell, A.L., et al., “Targeting HIV-1 to FcgammaR on human phagocytes via bispecific antibodies reduces infectivity of HIV-1 to T cells.” J. of Leuk. Biol. 55: 385-391 (1994).
Zaghouani, H., et al., “Induction of antibodies to the human immunodeficiency virus type I by immunization of baboons with immunoglobulin molecules carrying the principal neutralizing determinant of the envelope protein.” PNAS 92: 631-635 (1995).
Syrengelas, A.D., et al., “DNA Immunization induces protective immunity against B-cell lymphoma.” Nature Med. 2: 1038-1041 (1996).
Liu, C., et al., “Fcgamma RIII on Human B Cells Can Mediate Enhanced Antigen Presentation.” Cell. Immunol. 167: 188-194. (1996).
Liu, C., et al., “FcgammaRI-Targeted Fusion Proteins Result in Efficient Presentation by Human Monocytes of Antigenic and Antagonist T Cell Epitopes.” J. Clin. Invest. 98: 2001-2007. (1996).
Guyre, P.M., et al., “Increased Potency of Fc-receptor-targeted antigens.” Cancer Immunol. Immunother. 45: 146-148 (1997).
Boyle, J.S., et al., “Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction.” Nature 392: 408-411 (1998).
Guyre, P.M., et al., “Macrophage-targeted killing and vaccines.” Res. Immunol. 149: 655-660 (1998).
Serre, K., et al., “Efficient Presentation of Multivalentantigens Targeted to Various Cell Surface Molecules of Dendritic Cells and Surface Is of Antigen Specific B Cells.” J. Immunol. 161: 6059-6067. (1998).
Rodriguez, D., et al., “A human immunodeficiency virus type 1 Env-granulocyte macrophage colony-stimulating factor fusion protein enhances the cellular immune response to Env in a vaccinia virus-based vaccine.” J. of Gen Virol. 80: 217-223. (1999).
Biragyn, A.,et al., “Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity.” Nature Biotech. 17: 253-258. (1999).
Hayden-Ledbetter Martha
Ledbetter Jeffrey A
Marshall & Gerstein & Borun LLP
Parkin Jeffrey S.
Trubion Pharmaceuticals, Inc.
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