Compositions and methods for generating red chemiluminescence

Details Compositions and methods for generating red chemiluminescence Compositions and methods for generating red chemiluminescence

1999-05-03

2000-04-04

Kight, John

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

25230124, 252700, 548157, 435 6, 435 71, 435 79, 435 18, 435 21, 435 28, C12Q 100, C09K 1106, C07D27762

Patent

active

060459913

ABSTRACT:
Compounds which generate red chemiluminescence on reaction with a phosphatase enzyme are provided as well as intermediates useful for their preparation. The chemiluminescent compounds comprise a luciferin ring system and an exocyclic enol phosphate group where the position on the luciferin ring system adjacent to the double bond is disubstituted. The chemiluminescent compounds are useful alone or within compositions containing a cationic aromatic compound in methods for producing chemiluminescence. The chemiluminescent reactions can be applied in assays for phosphatase enzymes and in assays employing enzyme-labeled specific binding pairs.

REFERENCES:
patent: 5712106 (1998-01-01), Herrmann et al.

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