Sulphonamide derivatives as .alpha..sub.2 -adrenoceptor antagoni

Details Sulphonamide derivatives as .alpha..sub.2 -adrenoceptor antagoni Sulphonamide derivatives as .alpha..sub.2 -adrenoceptor antagoni

1987-07-09

1988-11-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 62, 546 70, A61K 31435, C07D47114, C07D491147, C07D49514

Patent

active

047882026

ABSTRACT:
The invention concerns sulphonamides of general formula ##STR1## and their pharmaceutically acceptable acid addition salts. In formula (I), R represents hydrogen or lower alkyl, R.sup.1 and R.sup.2 which may be the same or different each represents hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 and R.sup.4 which may be the same or different each represents lower alkyl, halo(lower)alkyl or aryl, A represents a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms and X represents O, S or NR.sup.5 (where R.sup.5 is hydrogen or lower alkyl). The compounds possess .alpha..sub.2 -adrenoceptor antagonistic activity in warm blooded animals.

REFERENCES:
patent: 4640924 (1987-02-01), White et al.
patent: 4686226 (1987-08-01), Huff et al.
patent: 4690928 (1987-09-01), Huff et al.

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