Elucidation and synthesis of antineoplastic tetrapeptide pheneth

Details Elucidation and synthesis of antineoplastic tetrapeptide pheneth Elucidation and synthesis of antineoplastic tetrapeptide pheneth

1992-12-03

2000-03-07

Huff, Sheela

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, A61K 3800

Patent

active

060340657

ABSTRACT:
Dolastatin 10, a linear pentapeptide, has shown potent antineoplastic activity profiles against various experimental cancer systems.
The design and synthesis of structural modifications of dolastatin 10 having significant antineoplastic activity against human cancer cell lines has been accomplished. Members of this group have demonstrated significant antineoplastic activity against selected human cancer cell lines. Especially: Ovarian OVSCAR-3; Central Nervous System ("CNS") SF295; Renal A498; Lung NCI460; Colon KM20L2 and Melanoma SK-MEL-3.

REFERENCES:
patent: 4978744 (1990-12-01), Pettit et al.
Correia Pharmac. Ther. vol. 52 (1991) pp. 127-147.
Jacobsen et al. J. of the Natl. Cancer Institute vol. 83 (22) pp. 1672-1677 .

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