Somatostatin analog and uses thereof

Details Somatostatin analog and uses thereof Somatostatin analog and uses thereof

2006-08-22

2006-08-22

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S016700, C530S328000, C530S329000

Reexamination Certificate

active

07094753

ABSTRACT:
Claimed is a somatostatin agonist according to formula (I),in-line-formulae description="In-line Formulae" end="lead"?D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2,   (I)in-line-formulae description="In-line Formulae" end="tail"?or a pharmaceutically acceptable salt thereof, and uses thereof.

REFERENCES:
patent: 4853371 (1989-08-01), Coy et al.
patent: 5590656 (1997-01-01), O'Dorisio et al.
Murphy, W.A. et al., “Octapeptide analogs of somatostatin exhibiting greatly enhanced in vivo and in vitro inhibition of growth hormone secretion in the rat,” Biochem. Biophys. Res. Comm., 1985, 132:922-928.
Colao, A. et al., “New medical approaches in pituitary adenomas,” Hormone Research, 2000, 50:76-87.
Ferone, D. et al.,, “In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: correlation with somatostatin and dopamine D-2 receptor scintigraphy,” Clin. Endocrinology, 2001, 54:469-477.
Saveanu, G. et al., “BIM-23244, a somatostatin receptor subtype 2- and 5-selective analog with enhanced efficacy in suppression growth hormone (GH) from Octreotide-resistant human GH-secreting adenomas,” J. Clin. Endocrinology and Metabolism, 2001, 86:140-145.
Shimon, I. et al., “Somatostatin receptor subtype specificity in human fetal pituitary cultures: differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation,” J. Clin. Investigation, 1997, 99:789-798.

Affiliated with

Also associated with

Rating

Somatostatin analog and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Somatostatin analog and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Somatostatin analog and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3630552