Process for making ondansetron and intermediates thereof

Details Process for making ondansetron and intermediates thereof Process for making ondansetron and intermediates thereof

2006-05-09

2006-05-09

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07041834

ABSTRACT:
A process useful for making ondansetron that comprises reacting a carbazolone in a reaction mixture comprising a carbazolone of formula (2), a formaldehyde or precursor thereof, and an amine of formula (3) in a non-aqueous polar solvent and in the presence of a water binding agent. The reaction product(s) can be reacted with an amine of formula (5) to form ondansetron. The water binding agent can improve the yield and/or speed of the reaction

REFERENCES:
patent: 4695578 (1987-09-01), Coates et al.
patent: 1105994 (1995-08-01), None
patent: 1107474 (1995-08-01), None
patent: 1110970 (1995-11-01), None

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