Process for the manufacture of 3-amino-pyrrolidine derivatives

Details Process for the manufacture of 3-amino-pyrrolidine derivatives Process for the manufacture of 3-amino-pyrrolidine derivatives

2006-06-20

2006-06-20

McKane, Joseph K. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C540S225000

Reexamination Certificate

active

07064199

ABSTRACT:
The invention is concerned with a process for the manufacture of vinylpyrrolidinone-cephalosporin derivatives from 3-amino-pyrrolidine derivatives of the formulawhereinR1signifies hydrogen or an amino protecting group;Z signifies hydrogen or an amino protecting group; and* represents a center of chirality.

REFERENCES:
patent: 0391169 (1990-10-01), None
patent: 1138672 (2001-10-01), None
patent: WO 9220652 (1992-11-01), None
Cicchi et al., “A Five Membered Enantiopure Cyclic Nitrone From Malic Acid By Regioselective Oxidation of Cyclic Hydroxylamine. Synthesis of (1S,7S,8aR)-Octahydro-1,7-dihydroxyindolizine,”J. Org. Chem., 60:4743-4748 (1995).

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