Polynucleotide encoding the enoyl-acyl carrier protein...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S254110, C435S320100, C435S325000, C435S455000, C435S471000, C536S023100, C536S023200, C536S023400

Reexamination Certificate

active

06995254

ABSTRACT:
Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat infections, such as staphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.

REFERENCES:
patent: 5539132 (1996-07-01), Royer et al.
patent: 5614551 (1997-03-01), Dick et al.
patent: 5759837 (1998-06-01), Kuhajda et al.
patent: 5965402 (1999-10-01), Black et al.
patent: 6228619 (2001-05-01), Foster et al.
patent: 6274376 (2001-08-01), Black et al.
patent: 6380370 (2002-04-01), Doucette-Stamm et al.
patent: 6403337 (2002-06-01), Bailey et al.
patent: 6432670 (2002-08-01), Payne et al.
patent: 6593114 (2003-07-01), Kunsch et al.
patent: 6753172 (2004-06-01), Payne et al.
patent: 2002/0076766 (2002-06-01), Black et al.
patent: 2004/0053814 (2004-03-01), Brandt et al.
patent: DT 26 20 777 (1977-12-01), None
patent: 0 786 519 (1997-07-01), None
patent: 0 826 774 (1998-04-01), None
patent: 10-174590 (1998-06-01), None
patent: WO 97/30070 (1997-08-01), None
patent: WO 97/30149 (1997-08-01), None
patent: WO 00/70017 (2000-11-01), None
patent: WO 01/30988 (2001-05-01), None
patent: WO 01/48248 (2001-07-01), None
patent: WO 02/31128 (2002-04-01), None
Ngo et al., “Computational complexity, protein structure prediction, and the Levinthal paradox”, Chapter 14 in ‘The Protein Folding Problem and Tertiary Structure Prediction’, Merz et al. (eds.), Birkhauser: Boston, MA, pp. 433 & 492-495, 1994.
Turnowsky et al., “envM genes ofSalmonella typhimuriumandEscherichia coli”, J. Bacteriol. 171 (12): 6555-6565, Dec. 1989.
Bergler, et al., (1994),J. Biol. Chem., 269: pp 5493-5496.
Heath, et al., (1996),J. Biol. Chem., 271: 1833-1836.
Heath, et al., (1995),J. Biol. Chem., 270: 26538-26542.
Grassberger, et al., (1984),J. Biol. Chem., 27: 947-953.
Gronowitz, et al.,Acta Pharma Suecica,(1971), 8: 377.
Bergler, et al., (1992),J. Gen. Microbiol., 138: 2093-2100.
Lam, et al.,J. Antimirob. Chemother.,(1987), 20: 37-45.
Broadwater et al., “Spinach Holo-Acyl Carrier Protein: Overproduction and Phosphopantetheinylation inEscherichia coliBL21(DE3), in Vitro Acylation, and Enzymatic Desaturation of Histidine-Tagged Isoform Ii”, Protein Expression and Purification 15, 314-326 (1999).
Edwards, et al., “Cloning of the fabF gene in an expression vector and in vitro characterization of recombinantfabFandfabBencoded enzymes fromEscherichia coli”, FEBS Letters,402:62-66 (1997).
Lambalot, et al., “Cloning, Over production, and Characterization of theEscherchia coliHolo-acyl Carrier Protein Synthase*”, The Journal Biological Chemistry, vol. 270, No. 42, pp. 24658-24661 (1995).
Rock et al., “Preparative Enzymatic Synthetic and Hydrophobic Chromatography of Acyl-Acyl Carrier Protein”,The Journal of Biological Chemistry,254(15): 7123-7128 (1979).
Rock et al., “Acyl Carrier fromEscherichia coli”. Methods in Enzymology,71:341-351 (1981).
Roujeinikova et al., “Inhibitor Binding Studies on Enoyl Reductase Reveal Conformational Changes Related to Substrate Recognition”,The Journal of Biological Chemistry,274(43): 30811-30817 (1999).
Ward et al., “Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan”, Biochemistry, 38:12514-12525 (1999).
U.S. Appl. No. 09/292,411, filed Apr. 15, 1999, Fab I, Issued: U.S. Pat. 6,753,172; Jun. 22, 2004.
U.S. Appl. No. 09/292,412, filed Apr. 15, 1999, Polynucleotides Encoding Staphyloccal Fab I Enoyl-Acp Reductase (as Amemded), Issued: U.S. Pat. 6,432,670; Aug. 13, 2002.
U.S. Appl. No. 10/089,019, filed Oct. 26, 2000, Methods for Making and Using Fatty Acid Synthesis Pathway Reagents, pending.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polynucleotide encoding the enoyl-acyl carrier protein... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotide encoding the enoyl-acyl carrier protein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide encoding the enoyl-acyl carrier protein... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3625722

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.