Redirection of cellular immunity by receptor chimeras

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

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ABSTRACT:
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.

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