Prevention and treatment of peripheral neuropathy

Details Prevention and treatment of peripheral neuropathy Prevention and treatment of peripheral neuropathy

1993-04-16

1995-05-30

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 21, A61K 3800, A61K 3804, A61K 3808, A61K 3822

Patent

active

054201128

ABSTRACT:
The invention features a method of preventing or treating a peripheral neuropathy that results from a systemic disease (e.g., post-polio syndrome) or a toxic agent (e.g., a chemotherapeutic agent), and that is not caused by an abnormal insulin level in a mammal. The method involves administering a neuropathy-reducing amount of insulin-like growth factor-I (IGF-I) or insulin-like growth factor-III (IGF-III) to the mammal.

REFERENCES:
patent: 4863902 (1989-09-01), Amagase et al.
patent: 5068224 (1991-11-01), Fryklund et al.
Guroff, G. Annals NY Academy of Sciences, 692 56-59 (1993) Exhibit 1.
Ekstrom et al. Ana NY Acad Sci 692: 291-93, (1993) Exhibit 2.
Apfel et al., "Nerve Growth Factor Prevents Toxic Neuropathy in Mice," Annals of Neurology 29:87-90, 1991.
Shiraishi et al., "The effect of Vincristine on Nerve Regeneration in the Rat: An Electrophysiological Study," Journal of the Neurological Sciences 71:9-17, 1985.
Bothwell, "Insulin and Somatemedin MSA Promote Nerve Growth Factor-Independent Neurite Formation by Cultured Chick . . . Neurons," Journal of Neuroscience Research 8:225-231, 1982.
Apfel et al. 1992, Ann. Neurol. 31:76-80.
Francis et al. 1992, Art to Science in Tissue Culture. Hyclone Laboratories Inc. 11:pp. 3, 5, 6, 7.
De Angelis et al. 1991, Cancer 67:2241-2246.
Olesen et al. 1991, Drug Safety 6:302-314.
Caroni et al. 1990, The Journal of Cell Biology 110:1307-1317.
Recio-Pinto et al. 1988, Neurochem. Int. 12:397;14 414.
Aizenman et al. 1987, Brain Research 406:32-42.
Ishii et al. 1987, In:Insulin, IGFs, and Their Receptors in the Central Nervous System (Raizada M. K. and Phillips M. A., eds), pp. 315-348. Plenum Press, New York.
Mengs et al. 1987, European Journal of Pharmacology 142:419-424.
Hansson et al. 1986, Acta. Physiol. Scand. 126:609-614.
Legha, Sewa S. 1986, Medical Toxicology 1:421-427.
Ross et al. 1981, The Journal of Neuroscience 1:1304--1311.

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