Polymeric carriers for non-covalent drug conjugation

Details Polymeric carriers for non-covalent drug conjugation Polymeric carriers for non-covalent drug conjugation

1993-07-26

1995-05-30

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

4241781, 514 8, 514387, 530350, 530363, 530367, 530370, 530392, 530409, 5483041, A61K 31415, A61K 4742, A61K 4748

Patent

active

054201055

ABSTRACT:
Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. A polymeric carrier may be attached to a proteinaceous or a non-proteinaceous ligand or anti-ligand to form a conjugate useful in pretargeting protocols to deliver a drug to target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.

REFERENCES:
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patent: 5106951 (1992-04-01), Morgan, Jr. et al.
patent: 5204448 (1993-04-01), Subramanian
patent: 5225325 (1993-07-01), Miller et al.
patent: 5252713 (1993-10-01), Morgan, Jr. et al.
patent: 5273743 (1993-12-01), Ahlem et al.
patent: 5283342 (1994-02-01), Gustavson et al.
patent: 5328985 (1994-07-01), Sano et al.
J. Immunology, vol. 139, No. 7, issued 01 Oct. 1987, Glennie et al, "Preparation and Performance of Bispecific . . . ", pp. 2367-2375.

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