Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-10-31
2000-03-07
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 234, 530350, C12N 1531, C12N 1562, C12N 1563, C12N 1574
Patent
active
060338776
ABSTRACT:
This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenzae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displayed a heterologous or homologous peptide sequence having biological activity. The fusion protein may be expressed on the surface of the host cell, such as in H. influenzae, which has been transformed with a fusion sequence that is operatively linked to at least one regulatory control element for expression of the fusion protein. Alternatively, the fusion protein can be purified from the host cell in the expression system, if the fusion protein remains associated with the host cell; or from the media of the expression system, if the fusion protein is a secreted form.
REFERENCES:
patent: 5348867 (1994-09-01), Georgiou et al.
Haase et al. Mapping of Bacterial Epitopes on the P2 Porin Protein of Nontypable Haemophilus influenzae. Infect. Immun. 62: 3712-3722, Sep. 1994.
Davies, J. M, Molecular mimicry: Can epitope mimicry induce autoimmune disease? Immunol. Cell Biol. 75(2): 113-126, Apr. 1997.
Haase et al., "Mapping of Bactericidal Epitopes on the P2 Porin Protein of Nontypeable Haemophilus influenzae", Sep. 1994, vol. 62: 3712-3722.
Murphy Timothy F.
Yi Kyungcheol
Guzo David
Larson Thomas G.
Research Foundation of State University of New York
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