Sequence specific DNA binding by p53

Details Sequence specific DNA binding by p53 Sequence specific DNA binding by p53

2006-08-08

2006-08-08

Martinell, James (Department: 1634)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

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07087583

ABSTRACT:
Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.

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