Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-10-24
2006-10-24
Woitach, Joseph (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S001100, C435S070100, C435S021000, C435S455000, C530S387100
Reexamination Certificate
active
07125713
ABSTRACT:
This invention discloses a substantially pure population of human Müllerian duct-derived epithelial cells and methods of isolating and culturing the Müllerian duct-derived epithelial cells. By carefully manipulating the microenvironment in which the Müllerian duct-derived epithelial cells are grown, multiple passages are attainable wherein the Müllerian duct-derived epithelial cells are capable of becoming uterine, cervical, vaginal, and oviductal cells. In addition, several uses of human Müllerian duct-derived epithelial cells and cells differentiating therefrom are disclosed herein.
REFERENCES:
patent: 6004528 (1999-12-01), Bergstein
patent: 6194203 (2001-02-01), Blum et al.
patent: 6416999 (2002-07-01), Li et al.
patent: 0 802 257 (1997-10-01), None
patent: WO-01/077298 (2001-10-01), None
patent: WO-01/077298 (2001-10-01), None
Barnes and Sato, (1980). “Methods for growth of cultured cells in serum-free medium”Anal. Biochem. 102:255-270.
Buck et al., (1982). “Monoclonal antibodies specific for cell culture mycoplasmas”In Vitro18(4):377-381.
Freshney, R.I. (ed), (1987).Animal Cell Culturepp. vii-xii. (Table of Contents).
Ganong, William F., (1991). “The gonads: Development & function of the reproductive system”in Review of Medical Physiology, fifteenth edition, Appleton and Lange, (eds), Chapter 23, pp. 387-425.
Ham and McKeehan, (1979). “Media and growth requirements”Meth. Enzy. 58:44-93.
Harlow and Lane (eds), (1988).Antibodies, A Laboratory Manualpp. iii-ix. (Table of Contents).
Jacob et al., (1999). “Early development of the Müllerian duct in avian embryos with reference to the human”Cells Tissues Organs164:63-81.
Jacobi, P. et al. (1997). “Expression of the CD15 Differentiation Antigen in the Reproductive Tract of the Female Rat During Fetal and Early Postnatal Ontogeny,”Histochem. Cell Biol. 108:57-66.
Köhler et al., (1975). “Continuous cultures of fused cells secreting antibody of predefined specificity”Nature256:495-497.
Lawrence et al., (1992), “An ultrastructural study of the developing urogenital tract in early human fetuses”Amer. J. Obstetrics/Gynecol. 167:185-193.
Mather, Jennie P. and Roberts, Penelope E., (1998).Introduction to Cell and Tissue CulturePlenum Press, New York pp. xi-xv. (Table of Contents).
Paranko, J. and Virtanen, I. (1986). “Epithelial and Mesenchymal Cell Differentiation in the Fetal Rat Genital Ducts: Changes in the Expression of Cytokeratin and Vimentin Type of Intermediate Filaments and Desmosomal Plaque Proteins,”Develop. Biol117:135-145.
Pellegrini et al., (1997). “Emx2developmental expression in the primordia of the reproductive and excretory systems”Anat. Embryol. 196:427-433.
Pisani et al., (1993). “Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden”Int. J. Cancer55:891-903.
Stephan, Jean-Philippe et al., (Dec. 1997). “Characterization of Cell Surface Proteins Using Antibodies Raised to Antigens From Pancreatic Cell Lines,” Abstract 1905-presentation materials:17 pages.
Taylor et al., (1997). “A conservedHoxaxis in the mouse and human female reproductive system: Late establishment and persistent adult expression of theHoxacluster genes”Biol. Reprod. 57:1338-1345.
Viehban, C. et al. (1987). “The Mesonephric (Wolffian) and Paramesonephric Müllerian Ducts of Golden Hamsters Express Different Intermediate-Filament Proteins During Development,”Differentiation34:175-188.
MacLaughlin, D.T. et al. (1992). “Mullerian Duct Regression and Antiproliferative Bioactive of Mullerian Inhibiting Substance Reside inits Carboxy-Terminal Domain,” Endocrinology 131:291-296.
Tsuji, M. et al. (1992). “Effect of Human Recombinant Mullerian Inhibiting Substance on Isolated Epithelial and Mesenchymal Cells During Mullerian Duct Regression in the Rat,” 131(3):1481-1488.
Kelch, R.P. et al. (1971). “Testoterone Metabolism in Target Tissues: 2. Human Fetal and Adult Reproductive Tissues, Perineal Skin and Skeletal Muscle,” 32:449-456.
Josso, N. et al., (1971) “Interspecific character of the mullerian-inhibiting substance: action of the human fetal testis, ovary and adrenal on the fetal rat mullerian duct in organ culture”J. Clin. Endocr. 32:404-409.
Magro, G. et al. (1995) “Expression of cytokeratins, vimentin and basement membrane components in human fetal male mullerian duct and perimullerian mesenchyme”Acta Histochemic(97):13-18.
Loo, D.T. et al. (Apr. 10, 1987). “Extended Culture of Mouse Embryo Cells Without Senescence: Inhibition by Serum,”Science236(4798):200-202.
Mather, J.P. et al. (1979). “The Use of Hormone-Supplemented Serum-Free Media in Primary Cultures,”Experimental Cell Research124:215-221.
Li Rong-hao
Mather Jennie Powell
Morrison & Foerster / LLP
Raven biotechnologies, inc.
Woitach Joseph
LandOfFree
Human mullerian duct-derived epithelial cells and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human mullerian duct-derived epithelial cells and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human mullerian duct-derived epithelial cells and methods of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3615588