Pharmaceutical composition

Details Pharmaceutical composition Pharmaceutical composition

1989-05-25

1991-05-28

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, C08B 3716, A61K 31715

Patent

active

050195638

ABSTRACT:
Complexes of .beta.-cyclodextrin with various salts of ibuprofen are described in which the molar ratios of ibuprofen to .beta.-cyclodextrin are within the range of from 1:0.20 to 1:0.75. The preferred salt of ibuprofen is the sodium salt. The complexes have enhanced taste profile and bioavailability. Also disclosed are methods for preparing the complexes and also pharmaceutical compositions thereof.

REFERENCES:
patent: 4834985 (1989-05-01), Elger et al.
Cyclodextrin Technology, Kluwer Academic Publishers, Boston, 1988, pp. 79-91.
Int. J. Pharm., 28 (1986) 95-101 (Chow et al).
Acta Pharm. Technol., 30(3) 1984, 213-223 (Jones et al).
Physiochemical Principles of Pharmacy, "Drug Interactions and Capabilities", .sctn. 10.10, pp. 433-435 (Florence & Attwood).

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