Methods and compositions in checkpoint signaling

Details Methods and compositions in checkpoint signaling Methods and compositions in checkpoint signaling

2006-09-05

2006-09-05

Nickol, Gary B. (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100

Reexamination Certificate

active

07101985

ABSTRACT:
The present invention is directed to compositions and methods regarding the signaling for the presence of DNA damage or replication stress and activating cell cycle checkpoints. Specifically, ATRIP was identified as an interactor with ATR, a member of the phosphatidylinositol kinase-related protein family that includes ATM and DNA-PK. In some embodiments, the present invention is directed to ATRIP and ATR acting as mutually dependent partners in cell cycle checkpoint signaling pathways.

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patent: 6307015 (2001-10-01), Elledge et al.
Zou, Lee, et a;.; Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes; Science (Jun. 6, 2003); vol. 300; pp. 1542-1548.
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GenBank Submission of NM—033628.Homo sapiensThre . . . .
GenBank Submission of AAH14153. hypothetical prot . . . .
GenBank Submission of XP—051515.hypothetical prot . . . .
GenBank Submission of XM—051516.
GenBank Submission of NM—130384.Homo sapiensthre . . . .
GenBank Submission of AL832917.Homo sapiensmRNA . . . .
GenBank Submission of NP—569055. three prime repai . . . .
GenBank Submission of AF451323.Homo sapiensATR . . . .
GenBank Submission of NP—115542. three prime repai . . . .
GenBank Submission of BC030597.Homo sapiens, thr . . . .
GenBank Submission of AB046054. Macaca fascicular . . . .
GenBank Submission of AK022405.Homo sapienscDNA . . . .
GenBank Submission of BC014153.Homo sapiens, hyp . . . .
GenBank Submission of NM—032166.Homo sapienshypo . . . .
GenBank Submission of AF319567.Homo sapiensclon . . . .
GenBank Submission of XP—054821. hypothetical prot . . . .
GenBank Submission of NP—115542. hypothetical prot . . . .
GenBank Submission of XM—051514.Homo sapienshypo . . . .
GenBank Submission of AF319566.Homo sapiensclon . . . .
GenBank Submission of XM—051513.Homo sapienshypo . . . .
GenBank Submission of XM—051515.Homo sapienshypo . . . .
GenBank Submission of XM—054821.Homo sapienshypo . . . .

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