Liposome composition for delivery of nucleic acid

Details Liposome composition for delivery of nucleic acid Liposome composition for delivery of nucleic acid

2006-09-26

2006-09-26

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C514S04400A

Reexamination Certificate

active

07112337

ABSTRACT:
A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delivery to a cell.

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