Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-07-28
1997-04-15
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483251, 5483255, 5483335, 5483345, 5483371, 5483381, 5483411, 5483425, 5483431, 5483435, 5483451, 5483421, 5483117, 5483154, 514396, 514397, 514400, A61K 31415, C07D23358, C07D40504
Patent
active
056209991
ABSTRACT:
A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower aralkenyl, lower aryloxyalkyl, lower arylthioalkyl and heteroaryl; wherein R.sup.3 is selected from lower alkyl and amino; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkyl and lower alkoxy; or where R.sup.4 together with the phenyl radical forms naphthyl or benzodioxolyl; provided R.sup.1 is not lower alkyl when R.sup.3 is methyl and when R.sup.4 is hydrido, methyl, methoxy or chloro; or a pharmaceutically-acceptable salt thereof.
REFERENCES:
patent: 3707475 (1972-12-01), Lombardino
patent: 3901908 (1975-08-01), Fitzi et al.
patent: 4175127 (1979-11-01), Dender et al.
patent: 4188397 (1980-02-01), Hill
patent: 4372964 (1983-02-01), Whitney
patent: 4472422 (1984-09-01), Whitney
patent: 4503065 (1985-03-01), Wilkerson
patent: 4576958 (1986-03-01), Wexler
patent: 4686231 (1987-08-01), Bender et al.
patent: 4822805 (1989-04-01), Takasugi et al.
T. Hla and K. Nielson, Proc. Natl. Acad. Sci, USA, 89, 7384 Aug. (1992).
J. Masferrer, et al, Proc. Natl. Acad.Sci, USA, 89, 3917 May (1992).
E. Meade et al, J. Biol. Chem., 268, 6610 Mar. (1993).
Futaki et al, Prostaglandins, 47, 55 Jan. (1994).
T. Sharpe et al, J. Med. Chem., 28, 1188 (1985) (S).
H. Greenberg et al, J. Org. Chem., 31, 3951 Dec. (1966).
T. van Es et al, J. Chem. Soc., 1363 (1963) (S).
J. Lombardino et al, J. Med. Chem., 17, 1182 (1974) (S).
Barta Thomas E.
Collins Paul W.
Stealey Michael A.
Weier Richard M.
Bulock Joseph W.
Richter Johann
Stockton Laura L.
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