Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1997-04-15
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514284, 514252, 514253, 514318, 514326, 514327, 514328, 514330, 514331, 544224, 544238, 544239, 544240, 546198, 546194, 546193, 546213, 546214, 546215, 546 77, 546217, 546219, 546221, 546228, 546234, A61K 31445, C07D21142
Patent
active
056209932
ABSTRACT:
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing orthostatic hypotension. One such tissue is found surrounding the urethral fining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.
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patent: 5488062 (1996-01-01), Dunlap et al.
J. Med. Chem., Wetzel et al., Discovery of Alpha 1a Adrenergic Receptor Antagonists Based on the L-Type Ca2+ Channel Antagonist Niguldipine, May 12, 1995, vol. 38, No. 10, pp. 1579-1581.
The Journal of Pharmacology & Experimental Therapeutics, vol. 241, No. 3, 1987, Rimele et al., Tissue-Dependent Alpha Adrenoceptor Activity of Buspirone and Related Compounds.
Bock Mark G.
Friedinger Roger M.
Patane Michael A.
Appollina Mary A.
Dahlen Garth M.
Ivy C. Warren
Merck & Co. , Inc.
Winokur Melvin
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