Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-08-29
2006-08-29
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S300000, C544S243000
Reexamination Certificate
active
07098341
ABSTRACT:
The present invention relates to a process for preparing haptens for immunoassay of phosphorothioate pesticides, which comprises the steps of reacting O-methyl(ethyl) dichlorothiophosphate with a phenolic compound to obtain O-methyl(ethyl) O-aryl chlorothiophosphate, and reacting the O-(methyl)ethyl O-aryl chlorothiophosphate thus obtained with aminocarboxylic acid to give desired haptens. In accordance with the present invention, haptens having a structure of O-methyl(ethyl) O-aryl N-(carboxyalkyl)phosphoramidothioate or O-methyl(ethyl) O-aryl N-alkyl-N-(carboxyalkyl)phosphoramidothioate can be simply prepared with a high yield by employing two-step processes in a cost-efficient manner.
REFERENCES:
Cho, et al., “Development of an ELISA for the Organophosphorus Insecticide Chlorpyrifos”, 2002, Korean Chem. Soc., 23:481-487.
Park, et al., “Development of an ELISA for the Organophosphorus Insecticide Isofenphos”, 2002, Korean Chem. Soc., 23:599-604.
Park e al., “Development of an Enzyme-Linked Immunosorbent Assay for the Organophosphorus Insecticide Cyanophos”, 2002, Korean Chem. Soc., 23:605-609.
Park, et al., “Development of an Enzyme-Linked Immunosorbent Assay for the Organophosphorus Insecticide Bromphos”, 2002 Korean Chem. Soc., 1399-1403.
Park, et al., “Development of an Enzyme-Linked Immunosorbent Assay for the Organophosphrous Fungicide Tolclofos-methyl”, 2002, Korean Chem. Soc., 24:334-338.
Kim, et al., “Synthesis of haptens for immunoassay of organophosphorus pesticides and effect of heterology in hapten spacer arm length on immunoassay sensitivity”, 2003, Analytica Chimica Acta, 475:85-96.
Kim, et al., “Synthesis of haptens of organophosphorus pesticides and development of enzyme-linked immunosorbent assays for parathion-methyl”, 2003, Analytica Chimica Acta, 493:47-62 (2003).
Kim, et al., Investigation of the Effect of Hapten heterology on immunoassay sensitivity and development of an enzyme-linked immunosorbent assay for the organophosphorus insecticide fenthion, 2003, Analytica Chimica Acta, 494:29-40.
McAdam, et al., “Synthesis of Organothiophosphate Antigens for the Development of Specific Immunoassays”, 1993, Aust. J. Chem., 46:959-967.
Skerritt, et al., “Approches to the Synthesis of Haptens for Immunoassay of Organophosphate and Synthetic Pyrethroid Insecticides”, 1996, American Chemical Society Symposium Ser. 621: 124-149.
Kim Yoo-Jung
Lee Hye-Sung
Lee Yong-Tae
Knobbe Martens Olson & Bear LLP
Lee Yong-Tae
McKane Joseph K.
Shiao Robert
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