Triazole compounds useful in therapy

Details Triazole compounds useful in therapy Triazole compounds useful in therapy

2006-08-01

2006-08-01

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S318000, C514S326000, C546S193000, C546S208000, C544S333000

Reexamination Certificate

active

07084145

ABSTRACT:
The invention provides compounds of formula (I),the pharmaceutically acceptable salts and solvates thereof, wherein A, B, R1, R2, and R7are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof as vasopressin V1Aantagonists.

REFERENCES:
patent: 6265426 (2001-07-01), Alanine et al.
patent: 574944 (1932-02-01), None
patent: 1293503 (2003-10-01), None
patent: WO 0158880 (2000-02-01), None
Kakefuda, A. et al., Bioorganic & Medicinal Chemistry, vol. 10, pp. 1905-1912, 2002, “Discovery of 4,5-Diphenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human V1AReceptor.”
Kakefuda, A. et al., J. Med. Chem., vol. 45, pp. 2589-2598, 2002, “Synthesis and Pharmacological Evaluation of 5-(4-Biphenyl)-3-methyl-4-phenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human Vasopressin V1AReceptor.”

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