Process for synthesis of acylated HMG-CoA reductase inhibitors f

Details Process for synthesis of acylated HMG-CoA reductase inhibitors f Process for synthesis of acylated HMG-CoA reductase inhibitors f

1993-05-11

1995-05-30

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

425280, 425921, C12P 1706

Patent

active

054200245

ABSTRACT:
An immobilized lipase is employed in an organic solvent to esterify diol lactone derivatives of HMG-CoA reductase inhibitors to form HMG-CoA reductase inhibitors of formula (I). ##STR1## This process allows for the efficient, one-step production of HMG-CoA reductase inhibitors of structural formula (I).

REFERENCES:
patent: 5223415 (1993-06-01), Conder et al.
Hills M J et al, BBA 1042:237-240 (1990).
Okamura S et al, BBA 575:156-165 (1979).
Jones J B, Tetrahedron 42:3351-3403 (1986).
Wang Y-F et al, J. Am. Chem. Soc. 110:7200-05 (1988).
Landrand G, Tetrahedron Letts 27:29-32 (1986).
Komagata D, J. Ant. Biot 39:1574-7 (1986).

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