Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1993-01-11
1995-05-30
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435170, 435177, 435872, 435843, 435840, C12P 1322, C12N 1102
Patent
active
054200237
ABSTRACT:
A process for producing L-phenylalanine at high rates of formation and in good yields is provided which comprises allowing a microorganism which belongs to the genus Nocardia and is capable of producing L-phenyl-alanine from phenylpyruvic acid or a salt thereof and an amino group donor to act upon an aqueous solution containing phenylpyruvic acid or a salt thereof and an amino group donor selected from the group consisting of ammonium salts and ammonia in a hydrogen gas atmosphere.
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ATCC Catalogue of Bacteria, 1985, pp. 149-150.
Goodfellow et al, The Biology of the Actinomycetes, 1984, Academic Press, pp. 77-79, 89-94 and 203.
Wong et al, "Enzyme-Catalyzed Organic Synthesis: NAD(P)H Regeneration Using Dihydrogen and the Hydrogenase from Methanobacterium Thermoautotrophicum", Journal of the American Chemical Society, vol. 103, pp. 627-628 (1981).
Tsuji et al, "Microbial Production of L-Phenylalanine", Chemical Abstracts, 105:59463t (Mar. 20, 1986).
T. Matsunaga, et al, "Regeneration of NAD(P)H by Immobolized Whole Cells of Clostridium butyricum Under Hydrogen High Pressure", Biotechnology & Bioengineering, vol. 29, No. 9, Sep. 1985, pp. 1277-1281.
Hilhorst et al, "Enzymatic Conversion of Apolar Compounds in Organic Media Using an NADH-Regenerating System and Dihydrogen as Reductant", FEBS letters, vol. 159, No. 1, 2 (Aug. 1983), pp. 225-228.
Kitamura Takanori
Matsunaga Tadashi
Kuraray Co. Ltd.
Marx Irene
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